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Relevance of Vascular Function Markers: Study on the Effects of Quercetin and Epicatechin on Blood Pressure and Vascular Function in (Pre)Hypertensive Subjects

The FLAVO-studie is a scientific study aimed at investgating if (and how) certain pure flavonoids can beneficially influence vascular function.

Aldosterone-induced microvascular dysfunction as a cause of salt-sensitivity in obesity?

To investigate whether increased aldosterone levels in obese individuals lead to impairment of microvascular function through reduction of NO-availability, and to establish the role of microvasculaire dysfunction in the pathogenesis of salt-…

The antihypertensive effect of spironolactone in oligo-anuric haemodialysis patients.

1. to study the effect of spironolacton and triamterene on blood pressure in anuric hemodialysis patients.2. to study the effect of treatment on body weight, serum elektrolytes, 24-hours sodium excretion, plasma aldosterone and renin concentrations…

A randomized, placebo-controlled, double blind, 4-period, cross-over trial, to study the effects of aliskiren, hydrochlorothiazide and moxonidine on endothelial dysfunction in obesity related hypertension

Primary objective: to compare changes in endothelial function in patients with obesity related hypertension after 8 weeks of treatment with aliskiren, moxonidine and HCTZ.Secondary objectives: to compare changes in the following parameters in…

Study on the effects of sodium and potassium on blood pressure, vascular function and renal function in untreated (pre)hypertensive subjects

The primary objective is to determine the effect of (1) increased sodium intake and (2) increased potassium intake on flow-mediated dilation (FMD) and systolic blood pressure (SBP) in untreated (pre)hypertensive subjects

A double blind, randomized placebo-controlled cross-over study on the cardiovascular effects of Salvia miltiorrhiza extract (Danshen) in patients with hypertension and hyperlipidemia

Our primary objective is to determine the effect of Salvia miltiorrhiza extract (Danshen) on hyperlipidemia, in particular LDL-cholesterol. Secondary objective is to investigate the effect of Danshen on hypertension. Further objectives are to…

A randomized, placebo-controlled, double blind, 4-period, cross-over trial, to study the effects of aliskiren, hydrochlorothiazide and moxonidine on endothelial dysfunction in obesity related hypertension

Primary objective: to compare changes in endothelial function in patients with obesity related hypertension after 8 weeks of treatment with aliskiren, moxonidine and HCTZ. Secondary objectives: to compare changes in the following parameters in…

Insulin-induced microvascular activity in patients with essential hypertension: a possible role for angiotensin II AT1-receptor blockers-Amendement 26-03-2008.

Main study:1. Does blockade of the angiotensin II AT1-receptor improve the insulin-induced microvascular effects in hypertensive patients.2. Does blockade of the angiotensin II AT1-receptor impair the insulin-induced mi-crovascular effects in…

Chocolate Intervention to Reduce Chronically Elevated blood pressure trial* CIRCE trial

To assess the effect of cocoa-containing drinks either rich in flavanols or rich in flavanols and theobromine on blood pressure in untreated subjects with high normal blood pressure (prehypertension) or grade I hypertension as measured by 24-hours…

DiEtary Sodium Intake effects on ertugliflozin-induced changes in GFR, reNal oxygenation and systemic hemodynamics: the DESIGN study, a randomized, placebo-controlled, cross-over study with ertugliflozin in people with type 2 diabetes

This study has been transitioned to CTIS with ID 2023-510257-42-01 check the CTIS register for the current data. Sodium-glucose cotransporter 2 (SGLT2) inhibitors lead to a lowering of blood pressure and confer cardiovascular and renal protection in…

Explorative study to investige the acid-base response to five sodium and potassium salts in patients with chronic kidney disease (5Z study)

Test the effect of five different sodium- and potassium salts in patients with chronic kidney disease.