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Randomized, double-blind, placebo-controlled oxytocin trial in children with Prader-Willi syndrome.
Effects on social behaviour.

To evaluate the effects of intranasal oxytocin versus placebo on social behaviour and also on eating behaviour in children with PWS.

A phase-I open label, balanced, randomized, crossover, two-groups, two-treatments, two-period, pilot study in healthy male subjects to determine the feasibility of a multiple dose dispenser for testosterone intranasal gel as measured by pharmacokinetics

The purpose of this study is to demonstrate the effectiveness of the multiple dose dispenser in comparison to the syringe as measured by a testsoterone pharmacokinetic profile

A randomized double blind cross-over trial of the effects of low dose and high dose hydrocortisone replacement therapy on cognition, quality of life, metabolic profile and somatosensation in patients with secondary adrenal insufficiency

The aim of this study is to investigate whether a physiologically low hydrocortisone (HC) dose is better for cognition as compared to a high hydrocortisone dose. In addition, quality of life, metabolic profile and somatosensation will be described…

The (cost)effectiveness of paricalcitol in the treatment of secondary hyperparathyroidism in hemodialysis patients.

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plasma testosterone levels in hypogonadal individuals treated with AndroGel, impact of showering shortly after application

to investigate whether showering shortly after Androgel application adversly affects plasma testosterone levels.

Evening versus Morning Administration of Levothyroxine: a randomised controlled double-blind trial

To study in a large randomised double-blind trial, if the administration of levothyroxine at bedtime significantly changes TSH and thyroid hormone levels compared to morning administration. Furthermore we want to evaluate the change of quality of…

A phase II study exploring the safety and efficacy of nintedanib (BIBF1120) as second line therapy for patients with eitherc differentiated and medullary thyroid carcinoma progressing after first line therapy.

The primary objective is to explore the efficacy of nintedanib (as measured by progression free survival) as second line therapy for patients with either differentiated or medullary thyroid cancer progressing after first line therapy.

Role of brown fat and skeletal muscle in post-prandial clearance of triglycerides during and after cold exposure

1. To examine the effect of cold on post-prandial triglyceride metabolism using a standardized meal test during and after cold exposure 2. To examine the relationship between cold-induced brown adipose tissue activity and the changes in…

Bioequivalence study of prednisolone and dexamethasone; corticosteriods revised

This study aims to re-examine the bioequivalence of prednisolone and dexamethasone at two different doses by assessing tissue specific glucocorticoids effects, including the immune system, brain functioning, hormonal axes, and renal parameters.

N- acetylcysteine treatment for skin picking in children and young adults with PWS: A randomized, doubleblind, placebo-controlled, cross-over trial.

To evaluate the effects of N-acetylcysteine (NAC; Fluimucil® in Dutch) on skin picking behaviour in children and young adults with PWS.