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Evening versus Morning Administration of Levothyroxine: a randomised controlled double-blind trial

To study in a large randomised double-blind trial, if the administration of levothyroxine at bedtime significantly changes TSH and thyroid hormone levels compared to morning administration. Furthermore we want to evaluate the change of quality of…

Oral Thyroid hormone In Healthy volunteers Study: an interventional study on the effect of thyroid hormone on coagulation and fibrinolytic parameters.

Primary objective:- To define the overall effect of oral Levothyroxine on coagulation parameters.Secondary objectives:- To define the specific effect of Levothyroxine on each tested coagulation parameters.- To define the specific effect of…

A phase II study exploring the safety and efficacy of nintedanib (BIBF1120) as second line therapy for patients with eitherc differentiated and medullary thyroid carcinoma progressing after first line therapy.

The primary objective is to explore the efficacy of nintedanib (as measured by progression free survival) as second line therapy for patients with either differentiated or medullary thyroid cancer progressing after first line therapy.

Comparison of two methods to improve the outcome of a ultrasound assisted fine needle aspiration biopsy (FNAB) of the thyroid gland.

Primary objective: - obtain an comparison in diagnostic results of two methods of ultrasound assisted fine needle aspiration biopsies (FNAB) of the thyroidal gland in the Jeroen Bosch hospital (JBZ).Secondary objective:- can the cytological thyroid…