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Ingenio Device Algorithm Study

To gather data to support global submissions/approvals for some models of the Ingenio device family.

Platelet reactivity in patients with Atrial Fibrillation and Coronary Artery Disease under IIa antagonists and Xa antagonists

Study endpoints: This study will capture the following endpoints: 1. To determine if use of IIa antagonist(Dabigatran) is associated with increased platelet activation as compared to Xa(Apixaban, edoxaban, rivaroxaban) 2. To determine if use of IIa…

Quinidine versus verapamil in short-coupled idiopathic ventricular fibrillation: An open label, randomized crossover pilot trial.

This study has been transitioned to CTIS with ID 2024-511190-30-00 check the CTIS register for the current data. To investigate the feasibility of a definitive RCT to assess the efficacy and safety of verapamil and quinidine in patients with short-…

The efficacy of flEcainide Compared To metOprolol in reducing Premature ventrIcular Complexes. An open label cross-over study in pediatric patients.

To test the acute effect of beta-blockers vs flecainide on the reduction of PVCs in a pediatric population. Secondary objectives are to perform a prospective evaluation of the effect of PVCs on LV function, to test the effect of reduction of PVCs by…

Elimination of ventricular premature beats and ventricular tachycardia with catheter ablation versus optimal anti-arrhythmic drug treatment

Primary Objective: The aim of this study is to compare efficacy of antiarrhythmic drugs (sotalol or combination of flecainide and verapamil) and catheter ablation in reducing VPB/VT burden in patients with symptomatic idiopathic VPB/VTs.

Rate Adaptive Atrial Pacing in Heart Failure Patients with Chronotropic Incompetence

Primary Objective The primary objective of this pilot study is to assess the ability of MV sensor driven rate adaptive atrial stimulation to restore the quality of life in CI heart failure patients.Secondary Objective(s)The secondary objectives of…

Thoracoscopic surgical versus catheter ablation approaches for primary treatment of persistent atrial fibrillation

This current study aims to assess a patient specific therapy plan for patients with persistent AF by randomizing catheter versus thoracoscopic ablation for PV isolation without adjuvant substrate ablation in those patients. Subjects will be…

Health effects due to inhalation of ultrafine particles in healthy volunteers. Multiple short-term exposures to UFP near Schiphol Airport.
A cross-over study

We hypothesize that the toxic potency of UFP from air traffic is comparable to road traffic after inhalation by healthy humans. Therefore, we aim to:* Identify acute effects of short-term inhalation of ultrafine particles right next to Amsterdam…