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Periodontitis and Rheumatoid Arthritis; a link by protein citrullination? A cross-over clinical trial

To assess periodontitis-with P. gingivalis in particular- as a pathogenic factor in disease progression of RA.

*Differences in effect of treatment with mepolizumab and benralizumab on resident and inflammatory eosinophils"

To test the hypothesis: the mode of action of benralizumab being ADCC will target both resident and inflammatoryeosinophils whereas mepolizumab only targets inflammatory eosinophils. This will achieved by a head-to-headcomparison of the presence of…

Local Responses to Food Allergens in Eosinophilic Esophagitis: Mechanisms and Clinical Application

1. To investigate different modes of allergen administration to the esophageal wall, by testing the effect on visible mucosal changes2. To investigate which immune cells become activated after allergen provocation 3. To investigate whether the…