6 results
In this study, we aim to investigate the difference in the anabolic postprandial bile acid response between an enteral and parenteral mixed meal test (MMT) in healthy lean men. This study is important because it may give a better understanding of…
The primary objective of this study is to examine to what extent hepatic glycogen is decreased after a prolonged overnight fast in healthy volunteers with a normal weight and low liver fat percentage.
Primary Objective: To investigate whether a two-week low compared to high GI/SFA diet reduces liver fat content. Exploratory Objectives: To investigate whether a two-week low compared to high GI/SFA diet:* reduces DNL* lowers the 24-hour glycemic…
Primairy objective:To determine the effect of a 4-week high SFA diet compared to a 4-week high fructose diet on hepatic insulin sensitivity (determined by insulin-stimulated suppression of endogenous glucose production).Secondary objectives: - To…
Metabolic effects of ketohexokinase inhibition in individuals with non-alcoholic fatty liver disease
Primary objective: determining the effect of the ketohexokinase inhibitor, PF-06835919, on hepatic insulin sensitivity in individuals with non-alcoholic fatty liver disease.Secondary objective: determining the effect of the ketohexokinase inhibitor…
The primary objective of this study is to investigate to what extent hepatic fat oxidation can be stimulated by lowering hepatic glycogen content during a prolonged overnight fast. The secondary objective is to investigate whether reductions in…