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The effect of wheat fiber on increase of fecal bulk

Investigate if an increased consumption of VITACEL Wheat Fiber can enhance fecal bulk. Furthermore, we want to demonstrate that the increased consumption of wheat fiber can increase stool frequency and consistency.

Modulation of immune function by parenteral fish oil in patients with Crohn*s disease and high inherent Tumor Necrosis Factor-alfa production, a randomized, single blinded, cross-over study

To evaluate the effect of parenteral supplementation of fishoil based emulsion (rich in omega-3 fatty acids) compared with a soy bean oil emulsion (rich in omega-6 fatty acids) on the leukocyte functions (amongst others production of TNF-α and other…

The effect of a potato based low-osmolaric glucose polymer drink on gastric distress and running performance*

To investigate whether two newly developed, potato based LOPG drinks with a different osmolarity and volume taken before exercise, differently affect gastric distress after both a short and long term exercise, running performance, and the rate of…

Randomized, Placebo-controlled Double-blind Cross-over Study to Evaluate the Effects
of Oligofructose on Stool Frequency in Constipated subjects

To study the effect of fructo-oligosaccharides on functional constipation.

Influence of an Acidic Beverage (Coca-Cola) on the exposure to Imatinib (GLIvec) after major gastrecTomY in patients with Gastrointestinal Stromal Tumors (ABILITY)

Since imatinib easily and rapidly dissolves at pH 5.5 or less, a lack of gastric acid secretion might be causing the decreased exposure in the patients that underwent major gastrectomy. Therefore we would like to study if the exposure to imatinib in…

The effect of glycopyrroniumbromide on nocturnal clozapine induced sialorrhea in psychiatric patients: a randomized, cross-over, double blind, placebo controlled trial with an extended open label phase (QUITSPIT study)

Main objective: to determine the effect, defined as the percentage of patients that show a clinical relevant improvement on the severity of complaints of nocturnal sialorrhea, of oral glycopyrroniumbromide in comparison with placebo in psychiatric…

Effect of Prucalopride on Gastroesophageal Reflux, Esophageal Motility and Gastric Emptying in healthy volunteers

To asses the effect of Prucalopride on esophageal contraction characteristics and lower esophageal sphincter pressure, gastric emptying and esophageal reflux parameters in healthy male subjects

Pharmacokinetic study of the HCV protease inhibitor bocePRevir and the proton pump inhibitor OMeprazOle (PROMO)

Primary objectiveTo determine the effect of multiple dose OME on the pharmacokinetics (AUC0-8h, Cmax, C8h) of BOC.Secondary objectives:To determine the effect of steady state BOC on the pharmacokinetics (AUC0-8h, Cmax, C8h) of multiple dose OME.To…

A Multicenter, Prospective, Single-Blind, Randomized, Controlled, Study of the Repair of Challenging Abdominal Wall Defects: Strattice TM in abdominal Wall Repair (StaR)

The primary objective of this clinical study is to compare the incidence of post-repair wound related complications, including hernia occurence/reccurence between challenging abdominal wall defects repaired with Strattice Reconstructive Tissue…

Oro-gastro-intestinal digestion of emulsified fat and how this digestion relates to colloidal stability and physiological responses

Primary Objective: To determine oral, gastric and duodenal lipid degradation of fat preloads .Secondary Objectives: To study how the oro-gastro-intestinal digestion of these fat preloads relates to: - Colloidal stability. For this we will monitor…

Desensitisation of ulcerative colitis patients intolerant for mesalazine treatment.

Primary endpoint:- Successful desensitization for Mesalazine in ulcerative colitis patients with a presumed history of intolerance for Mesalazine. Secondary endpoint:- To investigate if a presumed intolerance for Mesalazine may be reproducible in a…

A double-blind, randomized, placebo-controlled, two-centre, phase IIa pharmacodynamic cross-over study to assess the effect of AZD2516 on the total number of reflux episodes in healthy male volunteers

The primary aim of the study is to determine the effect of orally administered AZD2516 as a reduction of the number of reflux episodes, in comparison with placebo, over a period of approximately three hours after a meal, in healthy male volunteers.

The safety, tolerability, and analgesic efficacy of Δ9-THC (Namisol®) in chronic pancreatitis patients suffering from persistent abdominal pain

Primary Objective: - To investigate the efficacy of Namisol® after a single dose of Δ9-THC on the experienced pain intensity (measured by the VASpain in rest and on movement) in patients with chronic pancreatitis.Secondary Objectives:- To…

A Phase 1, open-label, randomized, 2-period crossover drug interaction study in healthy adult subjects to evaluate the effect of the Proton Pump Inhibitor Omeprazole on the pharmacokinetics of SSP-002358.

Primary:to examine the effect of co-administration with omeprazole on the pharmacokinetics of SSP-002358.Secondary:to provide additional safety information for SSP-002358 when administered alone or in combination with omeprazole.

Gastric emptying of plant sterol-containing mini drinks in different meal intake scenarios and their effect on gallbladder emptying

The aim of this study is to gain insight in the mechanisms that may be involved in the effects of plant sterol drinks on gastric emptying and gallbladder motility. In order to test this, we compare the different effects of the consumption of a plant…

A Double-Blind, Placebo-Controlled, Single Ascending Dose Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of CCX507-H in Healthy Male and Female Subjects

Primary:to evaluate the safety and tolerability of single oral doses of CCX507-H, over a range of 3 dose levels, in healthy male and female subjectsSecondary:to evaluate the following:* Single dose pharmacokinetic profile (PK) of CCX507-H over a…

Effect of amitriptyline in functional heartburn

To assess the effect of amitriptyline on gastro-esophageal symptom severity and on esophageal sensitivity to acid perfusion and balloon distension in patients with documented functional heartburn.

Endoluminal fundoplication with the Esophyx*-device versus proton-pump-inhibition in treatment of Gastro-esophageal reflux disease (GERD).

The purpose of this prospective randomized controlled trial is to demonstrate that the EsophyX-TIF procedure will be more effective than PPI therapy as a short and long-term treatment of GERD.

A phase 3, Multi-Center, Randomized, Placebo-Controlled Study to Evaluate the Clinical Efficacy and Safety of Induction and Maintenance Therapy with Abatacept in Subjects with Active Crohn's Disease (CD) who have had an Inadequate Clinical Response and/or Intolerance to Medical Therapy

Primary ObjectivesPlacebo-Controlled Induction Period: Primary Objective: Compare the proportion of subjects who have a clinical response (as defined by a reduction in Crohn*s Disease Activity Index [CDAI] >= 100 or an absolute CDAI score…

A Phase III, Multi-Center, Randomized, Placebo-Controlled Study to Evaluate the Clinical Efficacy and Safety of Induction and Maintenance Therapy with Abatacept in Subjects with Active Ulcerative Colitis (UC) who have had an Inadequate Clinical Response and/or Intolerance to Medical Therapy

Placebo-Controlled Induction Period Primary Objective: Compare the proportion of subjects who have a clinical response at Week 12 between the abatacept and placebo treatment regimens.Maintenance Period Primary Objective: Compare the proportion of…