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The effects of ethanol on gut wall integrity as measured by I-FABP and LBP

The aim of this study is to determine the immediate effects of oral alcohol consumption in healthy volunteers on gut wall integrity as measured by Intestinal Fatty Acid Binding Protein (I-FABP) and Lipopolysaccharide Binding Protein (LBP) These…

The effect of capsaicin and cinnamaldehyde on intestinal permeability, gallbladder motility and satiety

To obtain more information about the effects of capsaicin and cinnamaldehyde on the intestine, these substances will be infused directly in the duodenum. Hereafter, the permeability of the intestine, gallbladder motility and the effects on satiety…

Effects of citrulline on intestinal function during physical exercise

Specific research objectives:Investigate the effect of orally administered citrulline at:- Circulation of gastrointestinal (GI) system- The occurrence of GI damage, liver and kidneys- The GIpermeability - Production of amino acids- Endothelial…

The effect of moderate alcohol consumption on a human in vivo model of low-grade systemic inflammation in young, normal-weight men

Primary objective: To explore whether prolonged moderate alcohol consumption affects in vivo cytokine response after a low dose of LPS in young, normal-weight men.Secondary objectives: To explore whether prolonged moderate alcohol consumption-…

The effect of ethanol on intestinal permeability and integrity in healthy individuals

The study aims to investigate the effects of moderate ethanol drinking on the intestinal permeability and the tight junction complex. If there increase in the intestinal permeability, these effects will be investigated at molecular level.

The effect of serotonergic modulation on intestinal permeability and visceral perception in healthy individuals and IBS patients

We would like to modulate the serotonin system with acute tryptophan depletion (ATD) and 5-hydroxytryptophan (5-HTP). ATD is based on ingestion of an amino acid drink devoid of the precursor of serotonin and hence caused a decreased serotonin level…

Prokinetics to alter the position of the gastric acid pocket in Gastro Esophageal Reflux Disease

Our Objective is to show that the administration of prokinectics leads to an altered position of the acid pocket scintigraphically, and it thereby changes the rate of postprandial acid reflux episodes.

The effects of the different bread types of fully known composition on gastrointestinal symptoms in individuals with non-coeliac wheat sensitivity.

The primary objective of this study is to investigate the effects of breads made from well-characterised Bread wheat, Emmer wheat, or Spelt wheat of fully known composition each yeast (study A) or sourdough (study B) fermented on intestinal symptoms…

In vivo effects of amylase trypsin inhibitors from wheat in the human gut: proof of cause of non-coeliac wheat sensitivity in irritable bowel syndrome?

We aim to perform a proof-of-concept study to assess the effect of ATIs on the intestinal barrier and immune function in healthy volunteers. We hypothesise that the ATIs either directly affect the intestinal barrier function, or indirectly by…

Local Responses to Food Allergens in Eosinophilic Esophagitis: Mechanisms and Clinical Application

1. To investigate different modes of allergen administration to the esophageal wall, by testing the effect on visible mucosal changes2. To investigate which immune cells become activated after allergen provocation 3. To investigate whether the…