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The effect of wheat fiber on increase of fecal bulk

Investigate if an increased consumption of VITACEL Wheat Fiber can enhance fecal bulk. Furthermore, we want to demonstrate that the increased consumption of wheat fiber can increase stool frequency and consistency.

Randomized, Placebo-controlled Double-blind Cross-over Study to Evaluate the Effects
of Oligofructose on Stool Frequency in Constipated subjects

To study the effect of fructo-oligosaccharides on functional constipation.

Effect of Prucalopride on Gastroesophageal Reflux, Esophageal Motility and Gastric Emptying in healthy volunteers

To asses the effect of Prucalopride on esophageal contraction characteristics and lower esophageal sphincter pressure, gastric emptying and esophageal reflux parameters in healthy male subjects

The effect of serotonergic modulation on intestinal permeability and visceral perception in healthy individuals and IBS patients

We would like to modulate the serotonin system with acute tryptophan depletion (ATD) and 5-hydroxytryptophan (5-HTP). ATD is based on ingestion of an amino acid drink devoid of the precursor of serotonin and hence caused a decreased serotonin level…

The safety and gastro-intestinal tolerance of recombinant human lactoferrin (rhLF) in apparently healthy human volunteers

To study the safety and digestive tolerance of recombinant human Lactoferrin (rhLF) as expressed in milk of transgenic cattle.

The effect of CanChew®, cannabidiol (CBD) containing chewing gum on Irritable Bowel Syndrome

Investigate the effect of administration of CBD by means of CanChew® chewing gum versus a placebo on pain, IBS symptoms and perceived wellbeing in patients with IBS.

Impact of A2 milk versus conventional milk on intestinal health: a proof-of-concept study in Irritable Bowel Syndrome patients

This study will be done to gain insights in the effects of A2 milk on GI symptoms, and immune and defense parameters, in IBS patients. The information will gain more insights in the working mechanism of different types of beta-casein in individuals…

Ziverel for PPI-refractory reflux symptoms: efficacy and mechanisms of action in humans

To assess the effect of Ziverel on esophageal sensitivity to acid, mucosal barrier function and reflux symptoms in patients with PPI-refractory reflux symptoms.