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The antihypertensive effect of spironolactone in oligo-anuric haemodialysis patients.

1. to study the effect of spironolacton and triamterene on blood pressure in anuric hemodialysis patients.2. to study the effect of treatment on body weight, serum elektrolytes, 24-hours sodium excretion, plasma aldosterone and renin concentrations…

A single-center, prospective, placebo-controlled, double-blind, randomized, cross-over mechanistic intervention study to investigate the effect of empagliflozin on kidney function in people with either preserved or impaired kidney function with or without type 2 diabetes

We aim to investigate the renal hemodynamic effects of empagliflozin in people with either preserved or impaired renal function with T2DM and people with impaired renal function without T2DM, all with and without adenosine blockade.

Potassium handling in chronic hemodialysis patients in response to higher dialysate potassium

To analyze how potassium handling, volume and sodium status change in stable anuric chronic hemodialysis patients (CKD-5D) in response to higher dialysate potassium.

The role of skin sodium accumulation in chronic kidney disease

Main objectivesCohort study:To investigate the prognostic implications of skin sodium accumulation for CKD patients.Sodium excretion intervention study:To study the effect of increased renal sodium excretion, with and without aldosterone blockade,…

Effects of dialysis duration on brain perfusion and cognitive function in end-stage renal disease - short vs. long hemodialysis

Primary objective: To test in patients with ESRD whether a longer HD session (8 hours) compared with CHD limits the decline in cerebral blood flow.Secondary objectives: 1) to investigate whether a longer dialysis session is associated with superior…

Potassium supplementation in patients with chronic kidney disease and healthy subjects: effects on potassium and sodium balance

To investigate how acute potassium administration affects potassium and sodium balance in healthy subjects as compared to patients at different CKD stages, i.e., normal kidney function and stage 3b/4 CKD.

Explorative study to investige the acid-base response to five sodium and potassium salts in patients with chronic kidney disease (5Z study)

Test the effect of five different sodium- and potassium salts in patients with chronic kidney disease.