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A multi- center, randomized, cross-over study to demonstrate the efficacy of pudendal neuromodulation for the treatment of neurogenic overactive bladder

The purpose of this trial is to demonstrate the superior efficacy of pudendal neuromodulation in treating patients with neurogenic overactive bladder, who have failed conservative treatment, in a randomized cross-over trial.Symptoms of urinary…

An open-label, two-way cross-over, randomized study to assess the pharmacokinetics and safety/tolerability of intra-vaginal delivery of gonadorelin and oxybutynin in healthy female volunteers

1. To explore the pharmacokinetics (PK) of intra-vaginal delivery of gonadorelin and oxybutynin. 2. To assess the safety and tolerability of gonadorelin and oxybutynin delivery with a prototype intra-vaginal ring.

A RANDOMIZED, TWO-PERIOD, OPEN-LABEL, SINGLE DOSE CROSSOVER STUDY TO EVALUATE THE BIOEQUIVALENCE OF AQX-1125 IMMEDIATE RELEASE TABLETS AND CAPSULES IN HEALTHY VOLUNTEERS

The purpose of the study is to investigate how quickly and to what extent AQX 1125 in the tablet form and the capsule form are absorbed and eliminated from the body (this is called pharmacokinetics). The pharmacokinetics of AXQ 1125 after…

A randomized, placebo-controlled three-way cross-over study to compare the pulsatile intravaginal delivery of oxybutynin versus oral administration.

Primary• To compare the anticholinergic side effects between repeated intravaginal administration of oxybutynin with the vaginal MedRing device and repeated oral administrationSecondary• To explore the pharmacokinetics of oxybutynin and its main…