23 results
The first objective of this study is to evaluate the effect of standard HD with different dialysate calcium concentrations as well as HD combined with citrate-acid dialysate on the clearance of CPPs and second the effect of these different solutions…
Primary Objective: •To investigate the effect of dietary sodium restriction on blood pressure and use of antihypertensive medication in renal transplant recipients.Secondary Objective(s): •To investigate the effect of dietary sodium restriction on…
1. to study the effect of spironolacton and triamterene on blood pressure in anuric hemodialysis patients.2. to study the effect of treatment on body weight, serum elektrolytes, 24-hours sodium excretion, plasma aldosterone and renin concentrations…
Primary Objective: Primary endpoints will be renal (ERPF, GFR and FF) response to angiotensin II after low and high sodium diet in formerly preeclamptic patients compared to healthy controls. Secondary Objectives: Secondary endpoint will be systemic…
Primary:- to investigate the safety and tolerability of the study drug after multiple oral dosing in healthy volunteersSecondary:- to investigate the effect of the study drug on potassium clearance upon oral potassium challenge after multiple oral…
Measuring the effects of light therapy during hemodialysis on objective en subjective sleep parameters, sleepiness during dialysis, mood and melatonin rhythm. De results of this pilot study can be used to design a larger study on light therapy in…
Based on the hypothesis that hemodialysis with Hemocontol is associated with a greater and earlier increase in plasma vasopressin levels than standard dialysis, we examine whether there is a difference in the course of plasma vasopressin levels…
The aim of the present study is to compare the following transport characteristics for a modified 3.86% glucose PET preceded by a long (>8 hours) dwell with 3.86% glucose (PET A) and one preceded by a long dwell with 7.5% icodextrin (PET B),…
Objectives1. To investigate whether the improved hemodynamic stability with Hemocontrol dialysis is based on higher plasma levels of vasopressin or on enhanced activity of the sympathetic nervous system and/or inhibition of nitric oxide production.…
Primary objective:- to investigate the safety and tolerability after a single oral dose in healthy men and women of non-childbearing potential. Secondary objective:- to investigate the pharmacokinetic of a single oral dose in healthy men and women…
The main aim is to develop an intervention to change knowledge, communication and attitudes regarding renal replacement therapy (RRT). The second main aim is to investigate whether this intervention has an impact on the proportion of patients…
Serum hepcidin levels are elevated in hemodialysis patients and may contribute to functional iron impairment and thus to ESA-resistance. Kinetics of hepcidin in hemodialysis patients has not been studied in detail. This study is designed to provide…
The primary hypothesis of the study is that the use of icodextrin leads to a reduction in extracellular volume compared to glucose 2.27%, but that the effects of icodextrin and glucose 2.27% on plasma will not differ.
Primary research question: Is there a difference in plasma- and dialysate clearances of middle molecules and larger molecules, with different electrical charges, between treatment with standard haemodialysis, high-flux haemodialysis and on-line…
The main study parameter is the routine measurement of serum phosphate concentrations after 8 and 12 weeks. Other study parameters are compliance to phosphate binders and supplement-related complaints such as nausea, diarrhoea, flushing and itchness…
Objective: To test the efficacy and safety of percutaneous renal sympathetic denervation of the native kidneys in the treatment of uncontrolled hypertension in kidney transplant recipients.
See above.
Primary objectivesTo study whether Geranyl-Geranyl Acetone (GGA) reduces left ventricular (LV) diastolic dysfunction in patients with HFpEF compared to placebo (and to assess/confirm its effectiveness and safety in patients with HFpEF)Secondary…
This study aims at improving the knowledge concerning HV-HDF and thus helps to tailor the optimal ERRT for each individual patient.The following hypotheses will be tested:1. Intra-dialytic hemodynamic stability is better preserved during HV-HDF as…
Primary objective: To test in patients with ESRD whether a longer HD session (8 hours) compared with CHD limits the decline in cerebral blood flow.Secondary objectives: 1) to investigate whether a longer dialysis session is associated with superior…