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A Randomized, Double-Blind, Placebo-Controlled, 2-Period Crossover Study to Evaluate the Effect of Intranasal Esketamine on Cognitive Functioning in Healthy Subjects

To evaluate the effect of intranasal esketamine 84 mg on cognition, and duration of cognitive effects (if present), as assessed using a computerized test battery (Cogstate®).

Everyday social behaviour and mood in individuals with a family history of depression

This study aims to investigate how serotonin influences social functioning in healthy adults with a first-degree family member diagnosed with MDD. The primary goal is to investigate the effect of an experimental increase in brain serotonin on…

A single dose, 4-way crossover, double-blind, placebo-controlled, randomized study to investigate the effect of JNJ-42847922 on polysomnography (PSG) measures in subjects with major depressive disorder with insomnia who are stably treated with antidepressants.

Primary ObjectiveTo evaluate the effect of JNJ-42847922 on sleep latency (latency to persistent sleep [LPS]) in MDD subjects, stably treated with an SSRI/SNRI, who suffer from insomnia.Secondary Objectives* To investigate the safety, tolerability,…

A Double-blind, Randomized, placebo-controlled, 3-way crossover study to eValuate the single dose Effects of Intranasal eSketamine on saFety of on-road driving in healthy subjects(DRiVE SaFe)

The objective of this study is to investigate whether subjects who have taken esketamine, will be able to drive a car as soon as their cognitive function has been restored. The residual effects on driving performance will be compared to placebo.…

Mood, serotonin and social interaction

This project aims to study how changes in serotonin alter interpersonal functioning in adults with or without a first degree family member diagnosed with MDD. The primary goal is to investigate the effect of experimentally lowered brain serotonin…

A double blind, randomized, placebo controlled four way cross-over trial to investigate the effects of metoclopramide on central vasopressin release and HPA-axis activation

Primary:1. To establish the effect of MCP on the release of plasma AVP and subsequent ACTH and cortisol secretion in the absence of a 5HTP-challenge.2. To establish the effect of MCP on the release of plasma AVP and subsequent ACTH and cortisol…

The effects of Acute Tryptophan Depletion in individuals with a history of depression with and without anger attacks

The aim of this project is to test the hypothesis that MDD patients with disturbances in anger/aggression regulation have more serotonin disturbances, as a trait marker for relapse, than MDD patients without disturbances in anger/aggression…

A double-blind, randomized, placebo controlled, single oral dose, two way cross-over trial to investigate the effects of an orally administered 5-HTP challenge test on hypothalamic fMRS activation in healthy male volunteers.

Primary Objectives:- To investigate the effects of a single dose (plasma concentration) 5-HTP challenge test (5-HTP200mg/CBD100+50mg/granisetron2mg) on hypothalamic fMRS activation patterns in healthy male volunteers.Secondary Objectives:- To assess…

A double-blind, randomized, placebo-controlled, cross-over, single center, pharmacodynamic trial to collect data for quantitative modeling of HPA axis modulation with desmopressin and CRH in healthy volunteers

Primary objectives:1) Describe the PD effects on plasma ACTH and serum cortisol upon 100 µg hCRH injection with or without a preceding injection of 10 µg dDAVP 2 hours earlier and study the PK-PD relationship (*Block B*). In particular, the outcome…

Tryptophan depletion in Parkinson*s disease patients treated with deep brain stimulation of the subthalamic nucleus: effects on mood and motor functions.

Our objective is to assess the effect of TRP depletion on mood and behavior in PD patients treated with STN DBS. By doing, this, we hope to be able to identify risk factors for and mechanisms underlying psychiatric side effects of STN DBS.…

A Randomized, Double-Blind, Placebo-Controlled, 2-Period, 2- Treatment Cross-Over Study to Evaluate the Effects of Ketamine on Resting State Functional Brain Connectivity in Major Depressive Disorder Patients who fail to respond to a Selective Serotonin Reuptake Inhibitor (SSRI) or Serotonin Noradrenaline Reuptake Inhibitor (SNRI)

Primary objectiveTo evaluate the CNS effects of a single intravenous dose of ketamine on functional brain networks by performing resting state functional magnetic resonance imaging (fMRI) in major depressive disorder (MDD) patients who fail to…

Interventional, randomized, double-blind, placebo-controlled, single-ascending dose study part investigating the safety, tolerability, and pharmacokinetic and -dynamic properties of Lu AF90103 and a double-blind, cross-over study part investigating the safety profile after infusion of Lu AF90103 at two rates to healthy men.

* to evaluate the safety and tolerability of Lu AF90103 following single ascending intravenous (i.v.) doses* to investigate the pharmacokinetics (PK) of Lu AF90103 (prodrug) and Lu AF88361 (drug) in plasma and cerebrospinal fluid (CSF) following…

Deep brain stimulation of the medial forebrain bundle for patients with treatment-resistant depression

Establishing efficacy of MFB DBS for TRD by comparing active DBS with sham DBS. Secondary aims are establishing an adverse events profile, establishing effects on quality of life, cost-effectiveness, (neuro)psychological and neuroimaging measures.

Randomized, Double-Blind, Double-Dummy, Placebo-Controlled 4-way Crossover Study to assess the Pharmacodynamics and Pharmacokinetics of Oral and Intravenous S-Ketamine in Healthy Volunteers

Primary Objectives* To investigate the effects of PO and IV S-ketamine and its metabolite S-norketamine on functional CNS tests up to 6h (acute effects) and 24h (delayed effects) after administration using NeuroCart test battery in healthy subjects…

Effect of S-Ketamine on Body Perception in Healthy Adults

The aim of this project is to assess the acute effects of the N-methyl-D-aspartate receptor antagonist S(+)-Ketamine compared to placebo on body and self-perception, using cognitive experimental tasks and EEG in healthy volunteers.

Oxytocin and reactivity to infant signals in mothers postpartum depression

In a randomized control trial (RCT) with mothers with postpartum depressive symptoms the following main hypotheses will be tested:• Oxytocin will promote more sensitive caregiving during mother-infant interactions and while interacting with a life-…

Task-induced sensitized brain circuits during rTMS in major depressive disorder

The objective of this study is to detect whether stimulation during task induced activation of brainnetworks leads to a higher efficacy of rTMS and other neurobiological changes.

A Randomized, Double-blind, Placebo-Controlled, 3-Period Crossover Study Followed by 1 Open-label Comparator Period to Evaluate Central Pharmacodynamic Activity of TAK-653 in Healthy Volunteers Using Transcranial Magnetic Stimulation

The primary objective of the study is to determine whether TAK-653, in comparison to placebo, increases CNS excitability, assessed with TMS-evoked MEP in healthy subjects.Next to that, the study has the following goals: - To determine whether TAK-…

A randomised, double blind, placebo-controlled cross-over study to investigate the effects of intravenous S(+)-ketamine on brain activation in three groups of women: healthy participants, healthy participants prone to depression and patients with fibromyalgia.

Objective 1: To determine the effects of S-ketamine on brain activation in healthy women, healthy women prone to depression and fibromyalgia patients.Objective 2: To determine the effects of S-ketamine on mood and other depression-related behavioral…

A 2-Part, Randomized, Placebo-controlled, Double-blind, Single Ascending Dose Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-55375515 in Healthy Male Subjects

The purpose of this study is to investigate how safe the new compound JNJ55375515 is when it is administered to healthy subjects. JNJ-55375515 has been administered to humans before and will be investigated at various dose levels.It will also be…