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A phase 4, monocenter, prospective, randomized, placebo-controlled, double-blind, cross-over, mechanistic intervention trial to assess effect of 4-week Ertugliflozin (SGLT-2 inhibitor) therapy on renal (cortical and medullary) oxygenation as determined by BOLD-MRI and renal (cortical and medullary) oxygen consumption as determined by positron emission tomography (PET) using ¹¹C-acetate in patients with type 2 diabetes mellitus and healthy controls.

Despite multifactorial treatment approaches residual risk for the development and progression of DKD remains high and novel therapies to halt renal burden in T2DM are urgently needed. SGLT-2 inhibitors are a relatively recent additions to the…

MAASFLEX: A Double-Blind, Randomized, Phase IV, Mechanistic, Placebo-Controlled, Cross-Over, Single-Center Study to Evaluate the Effects of 2 Weeks Dapagliflozin Treatment on Nocturnal Substrate Oxidation, Glucose Metabolism and Muscle Mitochondrial Function in Individuals with Impaired Glucose Homeostasis

The primary objective is to examine the effects of dapagliflozin on nocturnal substrate oxidation in overweight or obese subjects with disrupted glucose homeostasis but without T2D.

Acute microbial switch study

In this project we aim to investigate whether we can precisely measure the changes in fermentation gas patterns after supplementation of a complex fibre mixture over a 36-hour period in both lean normoglycemic and insulin resistant and/or…

Longer-term effects of peanut consumption on brain function in older men and women.

The primary objectives are to investigate in older men and women the effect of 16-week peanut consumption on brain vascular function and brain insulin-sensitivity in cognitive-control brain areas, while we will also focus on changes in cognitive…

Explorative study to investige the acid-base response to five sodium and potassium salts in patients with chronic kidney disease (5Z study)

Test the effect of five different sodium- and potassium salts in patients with chronic kidney disease.

The NUTRIOME study: Precision nutrition and postprandial immune response

To acquire metabolic health data from three dietary challenge meals for thedevelopment of an algorithm for personalised dietary advice, and subsequentlytest the effectiveness of this personalised dietary advice compared to ageneral healthy diet…

Longer-term effects of wild blueberry consumption on brain function in older men and women

The primary objectives are to investigate in older adults the effect of 16-week wild blueberry consumption on (regional) vascular function and insulin-sensitivity in the brain, while we will also focus on changes in cognitive performance as assessed…

The role of the adrenergic system in hypoglycaemia induced inflammatory response in people with type 1 diabetes and people without type 1 diabetes-RAID-II

To examine the effect of adrenergic inhibition on the hypoglycaemia induced inflammatory response (e.g. leukocyte phenotype, cytokines, inflammatory proteins) by performing a hyperinsulinaemic hypoglycaemic glucose clamp alongside infusion of α-ARA…

Effects of daily protein supplementation on brain function in older adults with overweight or obesity

The primary objective is to investigate in overweight or obese older adults the effect of daily protein supplementation for two weeks with either a plant-derived protein or an animal-derived protein on vascular function and insulin-sensitivity in…

Algorithm update study for the Inreda AP

The primary objective of the study is to assess the performance of the updated algorithm software. The secondary objectives are to assess the safety and other performance parameters of the updated software algorithm. Additionally, another secondary…