Search for a trial

Double blind, randomized, 2-way cross-over, placebo controlled study to evaluate the therapeutic and preventive effect of GLPG1205 on nociceptive and inflammation/sensitization induced pain in the UVB sunburn model in healthy male subjects

PrimaryTo assess the preventative effect of GLPG1205 on nociceptive and inflammation/sensitization induced pain in the UVB sunburn model using HPTol upon multiple dosing of GLPG1205 versus placebo.SecondaryTo further assess the preventative effect…

Is Transcranial Magnetic Stimulation a potential tool for cognitive therapy in Multiple Sclerosis?

The aim of the proposed pilot study is to explore the efficacy of rTMS in inducing a (transient) localized increase in brain activity of MS patients which is hypothesized to be beneficial for cognitive functioning. This is the first step that needs…

An Open-Label Drug-Drug Interaction Study in Healthy Male Subjects to Explore the Effects of Single and Multiple Doses of JNJ-39393406 on the Pharmacokinetics of a Single Oral Dose of Midazolam

The purpose of this investigation is: • To examine the effect of single and multiple doses of the new drug JNJ-39393406 (the study medication) on absorption, metabolism and excretion by the body after single administration of the drug midazolam.• To…

Tryptophan depletion in Parkinson*s disease patients treated with deep brain stimulation of the subthalamic nucleus: effects on mood and motor functions.

Our objective is to assess the effect of TRP depletion on mood and behavior in PD patients treated with STN DBS. By doing, this, we hope to be able to identify risk factors for and mechanisms underlying psychiatric side effects of STN DBS.…

Individually optimized rocker profile and self-adapting insole to reduce the plantar peak pressure in Diabetic patients with loss of protective sensation

Offloading the peak plantar pressure in Diabetic patients with loss of protective sensation by using the self-adjusting insoles and individually optimized rocker profiles. The secondary objective is to evaluate the effect of the self-adjusting…

Acute effects of ketone monoester supplementation on brain function in older men with overweight

The primary objective is to evaluate in older men the acute effect of ketone monoester supplementation on (regional) brain vascular function and insulin-sensitivity, as quantified by the non-invasive gold standard magnetic resonance imaging (MRI)-…

Combination of an adjustable rocker profile and a self-adjusting insole in patients with Diabetes

Evaluate the effect of the adjustable rocker, the self-adjusting insole, and a combination of both on in-shoe plantar peak pressures in patients with diabetes related neuropathy.

Improving gait in hereditary spastic paraplegia: towards evidence-based and individually tailored rehabilitation

We aim to establish an essential step towards evidence-based and individually tailored gait rehabilitation in patients with HSP using the following objectives: 1. This study aims to identify the effect of ten 1-hour sessions C-mill training on gait…

Determination of the sleep improving effects of phenolics from an orange peel extract

The present study aims to determine whether hesperidin or a hesperidin/apigenin combined preparation can improve objective sleep duration and/or sleep quality, and/or improve perceived sleep quality and feelings of rest.