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A two-phased, randomized, double blind, placebo-controlled study of ECP002A (*9-THC) to determine safety, tolerability and efficacy in Multiple Sclerosis patients suffering from spasticity and pain.

Primary objective:*Evaluation of the efficacy of ECP002A (*9-THC) on spasticity in patients with MSSecondary objectives:*Evaluation of the efficacy of ECP002A (*9-THC) on pain in patients with MS*Evaluation of the tolerability of ECP002A (*9-THC) in…

Is Transcranial Magnetic Stimulation a potential tool for cognitive therapy in Multiple Sclerosis?

The aim of the proposed pilot study is to explore the efficacy of rTMS in inducing a (transient) localized increase in brain activity of MS patients which is hypothesized to be beneficial for cognitive functioning. This is the first step that needs…

Tryptophan enriched diet to improve affective and cognitive functions in patients with multiple sclerosis

The purpose of this study is to test the acute effects of a TRP enriched meal in a dose-dependent manner in MS patients. The results of MS patients without mood disturbances (control group) will be compared to MS patients with mood disturbances (…

A randomized, double-blind, placebo-controlled, cross-over study to assess the effects of fampridine on eye movements and nerve conduction and function in patients with multiple sclerosis (MS) and a unilateral or bilateral internuclear ophthalmoplegia (INO)

Primary objective: - to evaluate the effects of fampridine on eye movements in MS patients with a unilateral or bilateral INO. Secondary objectives:- to determine whether there is an association between MRI signal of the medial longitudinal…

A Phase 2b dose-finding study for SAR442168, a Bruton's tyrosine kinase inhibitor, in participants with relapsing multiple sclerosis

Primary: - To determine the dose-response relationship for SAR442168 to reduce the number of new active brain lesions. Secondary: - To evaluate efficacy of SAR442168 on disease activity, assessed by clinical and imaging measures.- To evaluate the…

Randomized, double blind, placebo- and active comparator- controlled 3-way crossover study in healthy subjects to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of ENX-201

To assess PK of MPhs and MP.