19 results
to investigate the analgesic effect of high frequency 10 Hz rTMS on experimental pain measured through quantitative sensory testing (QST) in healthy subjects.
- To investigate the biochemical response of ITF2984, defined as a reduction in (random) GH < 1.0 mcg/l and/or normalization of IGF-1.- To investigate the biochemical response of ITF2984, defined as a reduction of GH to no more than 2.5 mcg/l…
Primary objective: To evaluate the differences in digestion and absorption on the administration of enteral nutrition either gastric or distal to the ligament of Treitz in the jejunum.Secondary objective: To evaluate the differences in endocrine…
Main aim; to show that NicVAX attenuates nicotine induced CNS effects on brain activation and cognitive performance relative to placebo. The secondary aim; to evaluate how these changes in CNS stimulation alter subjective measures and the addictive…
Primary Objective: - To investigate the efficacy of Namisol® after a single dose of Δ9-THC on the experienced pain intensity (measured by the VASpain in rest and on movement) in patients with chronic pancreatitis.Secondary Objectives:- To…
The primary objective of this study is to evaluate the tolerance of a new smoothie-style paediatric sip feed compared to a standard paediatric sip feed for a period of 6 weeks in children in need of oral nutritional support. The secondary objectives…
This proposal entails a proof-of-concept study into the neuropsychological effects of memantine augmentation in a random cross-over comparison to placebo, as add-on treatment to ongoing clozapine in severely mentally ill (SMI) patients with…
The main question of this study is: *Is selective beta-blocker treatment safe and effective in reducing sympathetic overdrive, thereby improving RV function and remodeling in patients with iPAH?*.In addition to the determination of RVEF, we will…
The aim of this study is to evaluate whether a 30-minute episode of helium breathing in humans affects the ability of the immune system to respond to ex vivo stimulation in whole blood taken from healthy volunteers.
The aim of this study is to develop a valid and reliable instrument to estimate the extent to which gagging problems will interfere with adequate dental treatment and to evaluate possible progress after psychological treatment of gagging problems.
The primary objective is to examine the effect of body fat distribution on the physiological response to a dietary fat intervention. Physiological response will be evaluated as fatty acid kinetics (plasma and subcutaneous fat appearance), targeted…
To assess the effect of betahistine on the severity / intensity of motion sickness
Objectives: Primary Objective1. To evaluate the effect of KH176 on gait (Gaitrite®) parameters: step-length and variability in step-time and step-width in patients with a m.3243A>G mutationSecondary Objectives2. To explore the effect of KH176…
To investigate effect of tizanidine ER 12 mg on simulated driving performance, cognitive and psychomotor functions compared with placebo, tizanidine IR 8 mg (two 4 mg doses given 6.5 hours apart) and active-control in healthy subjects
Transiently improve episodic memory in early AD patients with precuneal gamma (40 Hz) tACS (main objective) and identify what functional brain activity/network changes underlie this memory improvement (secondary objective)
• To assess effects of a single oral dose of 160 and 1500 mg cannabidiol compared to placebo on a specific set of pain modalities• To assess effects of a single oral dose of 160 and 1500 mg cannabidiol compared to placebo on UVB- and capsaicin-…
To evaluate the effect of KH176 during a 4 week treatment period on the attention domain score of cognitive functioning, as assessed by the visual identification test of the Cogstate computerised cognitive testing battery.
The Primary objective is to confirm the maintenance of vigilance with SENS-111.Secondary objectives are:* to confirm the maintenance of working memory, and cognitive function; * to confirm the pharmacodynamics effect of SENS-111 on symptoms…