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Treatment of Chronic Idiopathic Cough (CIC) and Chronic Cough in patients with Idiopathic Pulmonary Fibrosis (IPF) with PA101.

The objectives of the study are as follows:*1. To assess the effectiveness of inhaled PA101 delivered via eFlow high efficiency nebulizer for treating chronic cough. Improvements in chronic cough will be assessed by measuring the change from…

Biomarkers for soft tissue damage in a rigid and a soft-layered spineboard

In this study we want to investigate if there are differences in cytokine and mFABp production when using a rigid and a soft-layered spineboard, in relation to tissue-interface pressures. Furthermore, redness of the skin and experienced comfort are…

The effect of glycopyrroniumbromide on nocturnal clozapine induced sialorrhea in psychiatric patients: a randomized, cross-over, double blind, placebo controlled trial with an extended open label phase (QUITSPIT study)

Main objective: to determine the effect, defined as the percentage of patients that show a clinical relevant improvement on the severity of complaints of nocturnal sialorrhea, of oral glycopyrroniumbromide in comparison with placebo in psychiatric…

Pressure and tissue deformation while using a regular and a newly developed soft-layered long spineboard.

The primary objective of this study is to evaluate if there are differences in the tissue-interface pressures, pressures inside the tissues and tissue deformation in the sacral area when volunteers lie on a regular spineboard versus a vacuum…

Short Term Effect of a Heat and Moisture Exchanger on Tracheal Mucociliary Clearance in Laryngectomized Individuals

Primary: Assessment of the short-term effect of a Heat and Moisture Exchanger on tracheal mucociliary clearance in laryngectomized individuals. Secondary: The relationship between clinical assessment, ciliary activity and mucociliary clearance.

Brimonidine Tartrate for the Treatment of Injection Related Erythema Associated with Sub-cutaneous Administration of Peginterferon beta-1a

Primary ObjectivesTo evaluate the IRE intensity/color mitigation effect of a single administration of Brimonidine tartrate in comparison with a vehicle gel (placebo).Secondary ObjectiveTo evaluate the IRE intensity/color mitigation effect of a…

Amitriptyline 10% or ketamine 10% cream in neuropatic pain: a randomised doubleblind, placebo-controlled, cross-over multicenter pilot study

The purpose of this study is to investigate the effect size in order to perform a power calculation for calculating a sample size for a powered RCT

Metabolism of curcumin in healthy volunteers

To investigate the metabolism of curcumin in healthy volunteers and the effects of piprine and a lipid liquid formulation.