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Aspirin provocation of patients with Systemic Mastocytosis

To determine the prevalence and severity of ASA-related allergic reaction in SM patients.

STUDY TO INVESTIGATE THE EFFECTS OF LEVOCETIRIZINE AND DIPHENHYDRAMINE ON COGNITIVE AND PSYCHOMOTOR FUNCTIONING DURING SIMULATED DIVING AT 2 BAR AND 4 BAR IN PROFESSIONAL NAVY DIVERS

Investigate the effects of levocetirizine, diphenhydramine and placebo on cognitive and psychomotor functioning during controlled simulated diving in a recompression chamber in professional navy divers at 10 mt (2 bar) and 30 mt (4 bar).

A randomized, placebo-controlled, double blind, 4-period, cross-over trial, to study the effects of aliskiren, hydrochlorothiazide and moxonidine on endothelial dysfunction in obesity related hypertension

Primary objective: to compare changes in endothelial function in patients with obesity related hypertension after 8 weeks of treatment with aliskiren, moxonidine and HCTZ.Secondary objectives: to compare changes in the following parameters in…

Systemic antihistamines in the treatment of attention-deficit/hyperactivity disorder (ADHD): a pilot study.

Primary objectiveTo assess whether the use of alimemazine improves symptoms of allergic diseases and ADHD, as scored by the parents using standardized questionnaires (Sample Snap IV rating scales)

The protective effect of levocetirizine on exercise induced airway obstruction in cold air.

Analyze the protective effect of levocetirizine (LEV), through the direct antagonism of airway H1 receptors and the inhibition of the release or production of other inflammatory mediators, against exercise induced airway obstruction.

A Pharmacokinetic and Pharmacodynamic Comparison of Prasugrel and Clopidogrel in Very Elderly versus Non-Elderly Aspirin-Treated Subjects with Stable Coronary Artery Disease

: The primary objective of this study is to demonstrate non-inferiority by pharmacodynamic (PD) analysis of the prasugrel 5-mg maintenance dose (MD) in aspirin-treated subjects >=75 years of age with stable coronary artery disease (CAD)…

A Pharmacokinetic and Pharmacodynamic Comparison of Prasugrel and Clopidogrel in Low Body Weight versus Higher Body Weight Aspirin-Treated Subjects with Stable Coronary Artery Disease

The primary objective of this study is to demonstrate non-inferiority by pharmacodynamic (PD) analysis of the prasugrel 5-mg maintenance dose (MD) in aspirin-treated subjects <60 kg with stable coronary artery disease (CAD) versus the…

The neurobiological basis of bias and disengagement;
Two neurotransmitter mechanisms implicated in visual spatial attention.

The goal of the current investigation is to test a new model that accounts better for results of pharmacological research. This model states that the cholinergic system underlies disengagement, and that the noradrenergic system underlies bias. Two…

Effects of methylphenidate on resting state connectivity in healthy controls and in adults with Attention Deficit Hyperactivity Disorder.

Primary Objective:The primary objective in the current trial is to use graph theory to examine how the organization of the functional brain network may be altered by the administration of methylphenidate. The main question we intend to answer in…

An early diagnosis of asthma in young children by using non-invasive biomarkers of oxidative stress/airway inflammation, and early lung function measurements

This research proposal tests the hypothesis that an early asthma diagnosis is possible by using non-invasive biomarkers of oxidative stress/airway inflammation in exhaled air, venous blood and assessments of lung function (airway resistance by means…

Cortisol and Emotional Memory

In this study, the relationship between deficits within emotional memory and different typologies of psychopathy (impulsive vs. instrumental) will be examined. Furthermore, the current research concerns the influence (either positive or negative) of…