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A randomised, single dose, crossover, open label, placebo controlled confirmatory study with interim analysis in healthy volunteers to characterise the acid neutralisation activity of Gaviscon Double Action Tablets in the fasted state, using an intragastric and oesophageal pH catheter

The primary objective of this confirmatory study is to investigate the acid neutralisation action of Gaviscon Double Action Tablets versus placebo tablets, within the stomach.The secondary objective of this study is to assess the safety of the test…

The effectiveness of intensive treatment on sympathetic hyperactivity. A randomized, cross-over trial in patients with chronic kidney disease and hypertension

The primary objective is to investigate if there is an incremental inhibiting effect on MSNA by increasing dosage valsartan above the presently advised dosage. We hypothesize that there will be a further decrease in MSNA as compared to the MSNA…

A Multicenter, Randomized, Open-label, Phase 3 Trial Comparing selpercatinib (LOXO-292) to Physicians Choice of Cabozantinib or Vandetanib in Patients with Progressive, Advanced, Kinase Inhibitor Naïve, RET-Mutant Medullary Thyroid Cancer (LIBRETTO-531)

Primary* To compare TFFS of patients with progressive, advanced, kinase inhibitor naïve, RET-mutant MTC treated with LOXO-292 versus cabozantinib or vandetanib.Secondary* To compare other efficacy outcomes, based on RECIST 1.1 criteria, observed in…

Hyperbaric Oxygen Therapy Induced Neuroplasticity in Post Stroke Patients Suffering Chronic Neurological Deficiencies

Effect of hyperbaric oxygen therapy (HBOT) on patients with chronic neurological deficiency due to stroke.