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Early or Late Intervention in high risk non ST elevation Acute Coronary Syndromes.

Primary 1. An immediate invasive approach (immediate angiography and revascularization when appropriate) results in a reduction of the combined incidence of death, re-infarction or recurrent ischemia at 30 days follow-up. Secondary 1. An immediate…

Pharmacokinetic-pharmacodynamic modeling of S(+)-ketamine in healthy volunteers.

We will investigate the relationship between S(+)-ketamine plasmaconcentrations and its analgesic effect to estimates the onset/offset times of ketamine and potency parameters for various analgesia tests. This will allow the safer administration of…