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Effects of aprepitant (Emend ®) on the pharmacokinetics of fentanyl.

Primary Objective: - to study the influence of administration aprepitant (Emend ®) on the clearance of fentanyl, in patients using a stable dose of the fentanyl patch (Durogesic ®).Stable dose is defined as using the same dose of fentanyl during at…

A randomised, double-blind, placebo-controlled crossover study to investigate the effect of buprenorphine on fentanyl induced effects on nociceptive thresholds and CNS functioning in opioid tolerant patients.

Primary objectives- To evaluate the effects of buprenorphine on fentanyl induced analgesia using the PainCart test battery in OT patients, when compared to placebo.Secondary objectives- To evaluate the effects of buprenorphine on fentanyl induced…

Morphine or Fentanyl for Refractory dyspnea in COPD

There are two main objectives for this study. First, we will investigate the following hypothesis: Fentanyl patches provide reduction of dyspnea compared to placebo, comparable to morphine, and with less side effects than morphine. Secondly, with…

Reversal of opioid-induced respiratory depression with opioid antagonists - a study in opioid naïve individuals and chronic opioid users under real-life conditions

This study has been transitioned to CTIS with ID 2024-518041-16-00 check the CTIS register for the current data. The goal of the studies is multiple:1. To describe the pharmacokinetics of intravenously administered fentanyl and sufentanil;2. To…