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A double blind, double dummy, randomized, placebo-controlled, 5 period cross-over study to examine the effect of PF-06273340 on evoked pain endpoints in healthy volunteers using pregabalin and ibuprofen as positive controls

To investigate the ability of PF-06273340 to demonstrate analgesic properties in healthy subjects for pre-specified primary endpoints using a panel of pain tests.

A double blind, double dummy, randomized, placebo-controlled, 5 period cross-over study to examine the effect of PF-05089771 alone and in combination with pregabalin on evoked pain endpoints in healthy volunteers using pregabalin and ibuprofen as positive controls

To investigate the ability of PF-05089771 to demonstrate analgesic properties in healthy subjects for pre-specified primary endpoints using a panel of pain tests.

Translational trial to explore the pharmacodynamic effects of multiple oral dose
administrations of tapentadol PR, pregabalin, and combinations of
both in an intradermal capsaicin hypersensitization model in healthy
subjects.

The purpose of the study is to investigate the optimal dose combination of both drugs in healthy volunteers who will undergo a pain test.

EFFECTS OF TAPENTADOL ON CHRONIC PAIN AND PARAMETERS OF CENTRAL SENSITIZATION. A PROSPECTIVE, OPEN LABEL, RANDOMIZED CROSS-OVER STUDY WITH PREGABALIN AS COMPARATOR,

The main objective is to determine the change in CS parameters upon administration of tapentadol in comparison to pregabalin in patients suffering from chronic pain that has a visceral or deep somatic origin.

A randomized, double-blind, double dummy, placebo-controlled, four-way cross-over study to investigate the analgesic effects and CNS effects of morphine and pregabalin in healthy subjects

Primary• To evaluate the analgesic effects of morphine, pregabalin and the two drugs as combination using PainCartSecondary• To evaluate the drug-sensitive central nervous system (CNS) functioning of morphine, pregabalin and the two drugs as…

Combined effect of Pregabaline and Oxycodone, and Lacosamide and Oxycodone, on breathing: an exploratory study in healthy volunteers
the POLO study

The objective of the study is to quantify the effect of pregabaline and lacosamide on oxycodone-induced respiratory depression.