53 results
Investigate the effect of adjuvant metformin therapy on insulin need and on glycaemic control in CFRD patients.
The primary objective of this study is to determine the antialbuminuric response of vitamin D analogue in addition to ACE-inhibitor and low-sodium diet, in renal patients.
The objective of this study proposal is to determine whether pharmacologic optimization of voriconazole by means of therapeutic drug monitoring (TDM) results in improved patient outcomes (efficacy and safety) and is more cost-effective compared to…
So far, only a few case-studies have been tried using neurofeedback in the treatment of dementia / cognitive decline. These indicate that there are behavioural changes and emotional changes next to cognitive changes. This will be the focus of this…
Research question:Does thin application of betamethasonvaleraat cream 0,1% on perniones lesions twice a day reduce the symptoms of patients as determined in 1st. line health care, with at least 10 mm expressed on a visual analogue scale, together…
Primary:- to determine the relative bioavailability of a solid formulation (capsule) of PSN821 compared with an oral suspension of the drug.Secondary :- to determine the effect of food on to determine the effect of a high fat meal or light breakfast…
The purpose of this study is: • To examine how the combined oral contraceptive pill, which consists of 30 micrograms ethinyl-estradiol and 150 micrograms levonorgestrel (for instance Microgynon 30®), will be absorbed, metabolized and excreted by the…
For Part A: the purpose of this part is to investigate the effect of multiple oral doses of the new study drug on how quickly and to what extent glimepiride is absorbed and eliminated from the body (this is called pharmacokinetics), if glimepiride…
The aim of this study is to gain insight in the mechanisms that may be involved in the effects of plant sterol drinks on gastric emptying and gallbladder motility. In order to test this, we compare the different effects of the consumption of a plant…
The primary objective of the study is to demonstrate clinically relevant statistical superiority in progression-free survival (PFS) with GClb compared to RClb and Clb alone and RClb compared to Clb [GClb vs Clb; GClb vs RClb; RClb vs Clb] in…
Primary objective:To evaluate efficacy of RO5185426 as a monotherapy compared to dacarbazine in terms of progression-free survival (PFS) and overall survival (OS) in previously untreated patients with advanced melanoma harbouring the BRAF V600E…
The central hypothesis of this project is that atorvastatin (added on standard antihypertensive treatment ARB) causes a substantial decrease in MSNA in hypertensive patients with CKD.
Comparing the metabolic response (oxygenuptake and ventilation) and symptom perception (borgscores for dyspnoea and fatigue) between neuromuscular electrical stimulation with low-frequency and high-frequency.
To assess the effects of single dose of 100 mg (±) 3, 4-Methylenedioxymethamphetamine (MDMA, "ecstasy") and/ or a single dose of alcohol (0.5 %0) on simulated driving performance (in a controlled experimental design).To assess the effects…
Primary: To explore the effect of the H1-antagonist hydroxyzine 50 mg on motor response, attention and impulsivity, using a test battery and task manipulations. Secondary: To explore the effect of the H1-antagonist hydroxyzine 50 mg on…
To investigate glycemic and insulinemic index of teff bread relative to wheat bread in healthy individuals.
The aim of the study is to demonstrate a basic mechanism that supports our hypothesis: Does increased respiratory function after administration of a bronchodilator in patients with COPD lead to elevated pulmonary retention of the harmful compounds…
The purpose of the study is to investigate how safe the compound is and how well the compound is tolerated. The study will also investigate how quickly and to what extent the drug is absorbed, metabolised (broken down into smaller parts) and…
To investigate the effects on satiety parameters of teff bread relative to wheat bread in healthy individuals. The secondary objectives are to study the effects of teff energy intake and on fermentation in the large bowel.
To investigate the effect of two different dosages of theobromine and caffeine (450 mg theobromine and 60 mg caffeine and 300 mg theobromine and 40 mg caffeine respectively) and placebo on mood and cognition in healthy subjects.