156 results
The aim of the study is twofold. The first is the impact of the investigational drugs and the registered product on safety, tolerability and the release of vessels studied and compared. The second is the speed with which the investigational drugs…
This study is therefore aimed at quantifying the relative contribution of the two major receptor systems involved in S(+)-ketamine and methadone induced analgesia and side effects (respiratory depression, sedation, miosis).
The main objective is to test the hypothesis that predictions are implemented in the human brain by modulating the strength of backward connections from higher-order to lower-order areas. This modulation of effective connectivity will be assayed by…
Primary objective• To assess the effect of cytochrome P450 3A4 enzyme (CYP3A4) induction by rifampicin on the pharmacokinetics (PK) of eribulin following intravenous (IV) administrationSecondary objectives• To assess the safety of eribulin when co-…
1) To assess insulin sensitivity and response in critically ill septic neonates and children. 2) To determine protein balance in septic, critically ill children at baseline and during a Hyperinsulinemic Euglycemic Clamp, while receiving standard or…
To determine the effect of protein content (low vs. high) and taste (sweet vs. savory) of a meal on satiety, measured by subsequent intake of 4 different food categories (low-protein sweet, low-protein savory, high-protein sweet, and high-protein…
This trial assesses the safety profile of GRT6005 in terms of its effect on respiratory function. Data on its effect on ventilation in a model of respiratory depression will be obtained and compared to fentanyl (a strong opioid with comparable…
The aim of this study is to access the effect of low and high VT (ml/kg) on pulmonary and systemic inflammatory responses and the release of oxygen and nitrogen free radicals in the paediatric patient with and without ALI.
The primary objective is to examine whether a combined treatment with rivastigmine (cholinesterase inhibitor) and citalopram (selective serotonin re-uptake inhibitor) will improve memory as compared to the treatment with either rivastigmine or…
To test if a new intervention, aimed at learning to use stop-rules in a flexible way(Stop Rule Management, SRM), has a more positive effect on the disability and quality of life of patient with non specific WREUP, than a regular rehabilitation…
The primary objective of this study is to demonstrate non-inferiority by pharmacodynamic (PD) analysis of the prasugrel 5-mg maintenance dose (MD) in aspirin-treated subjects <60 kg with stable coronary artery disease (CAD) versus the…
To compare the burden for pregnant women and diagnostic capabilities of the oral glucose tolerance test (75g and 50g) and blood glucose samples during the day.
The main objective is to elucidate the acute effects of an oral intake of either saturated, monounsaturated or polyunsaturated fatty acids on PBMC whole genome expression of obese and type 2 diabetic obese subjects. Secondary objectives are to…
In this study we will investigate whether there is cross tolerance for the effects of alcohol and cannabis. Therefore we will investigate both the pharmacodynamic and pharmacokinetic effects of a combined administration of cannabis and alcohol.
The objective of the study is to investigate whether the Out-Of-Office BPM device of Microlife, the WatchBP O3, is comparable to the Spacelabs 90217 device at 24h BP measurement. Secondary objectives: To investigate whether the implemented features…
The primary objective of this study is to establish the clinically relevance of extra protein supplementation on the height growth at children with Cystic Fibrosis. The secondary objectives of this study are to measure the effects of protein…
This study focuses on visceral overweight and stress, related to intake of highly rewarding foods and food choice. The main objective of the study is determination of the effects of consumption of highly rewarding high protein/fat foods compared…
The main objective of this study is to investigate the effects of a glucagon challenge on hepatic glucose production, abdominal subcutaneous glucose levels in type 2 diabetes patients with and without oral antidiabetics. In addition, endothelial…
Assess the effect of 2 doses (10 and 20 mg) dronabinol on driving performance compared to placebo in light and heavy cannabis users. The heavy users are used as a model for chronic use of dronabinol.