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A study to evaluate the relative bioavailability and effect of food on two 450mg MK-3682 Fixed-Dose Combination Formulations (MK-3682 /MK-5172 /MK-8408)

- To evaluate the pharmacokinetic (PK) parameters (AUC0-t, AUC0-*, Cmax, C24, Tmax, and apparent t1/2) of MK-3682 and its circulating metabolites (IDX20664 and IDX23267), MK-5172, and MK-8408 following administration of the fixed-dose combinations…

Decreasing social jetlag with blue-light reducing glasses in the evening compared to blue-LED-light emitting glasses in the morning

To elucidate in the same participants (late chronotypes with at least two hours of social jetlag) the changes in sleep timing, social jetlag and endogenous circadian phase of melatonin with more than two hours of social jetlag shielded from blue…

The influence of gravity and body orientation on protein digestion and absorption.

From Page 14 of the C1 research protocol document:Primary Objective: To determine if changes in gravity through alterations in post-prandial body position affects protein digestion and absorptionSecondary objectives: To determine if changes in…

Single-dose, randomized, double-blind, two-way crossover study for the demonstration of pharmacodynamic equivalence of enoxaparin (100 mg/mL) 100-mg subcutaneous injection. Manufactured by Rovi (Spain) to Clexane (100 mg/mL) 100-mg subcutaneous injection manufactured by Sanofi (EU) in healthy volunteers.

The purpose of the study is to investigate the effect on the body of enoxaparin manufactured by the Sponsor (this is called pharmacodynamics) and to compare it with the pharmacodynamic effect of Clexane®. In addition, it will be investigated to what…

The effect of breakfast test products on acute satiety scores in different test conditions.

The primary objective is to investigate the acute effect of five different breakfast test products (breakfast cereals or bread or traditional) on satiety scores (feelings of hunger, fullness, satiety, desire to eat, prospective food consumption). -…

A Study to Evaluate the Comparative Bioavailability of Formulation Batches of MK-3682A
Fixed-Dose Combination Tablet (MK-3682/MK-5172/MK-8742, 225 mg/50 mg/25 mg) in
Healthy Adult Subjects

Primary ObjectiveTo evaluate and compare the pharmacokinetic (PK) parameters (AUC0-t, AUC0-inf, Cmax, C24hr, Tmax, and apparent t*) of MK-3682 and its circulating metabolites MK-5172, and MK-8742 following administration of three test premarket…

Brimonidine Tartrate for the Treatment of Injection Related Erythema Associated with Sub-cutaneous Administration of Peginterferon beta-1a

Primary ObjectivesTo evaluate the IRE intensity/color mitigation effect of a single administration of Brimonidine tartrate in comparison with a vehicle gel (placebo).Secondary ObjectiveTo evaluate the IRE intensity/color mitigation effect of a…

PARROT: Postprandial plasma amino acid concentrations after dairy consumption

Primary: To compare postprandial plasma amino acid concentrations after ingestion of a fixed amount of protein from different dairy products in elderly subjectsSecondary: To determine effects of a fixed amount of protein from different dairy…

Feasibility study: Studying the effect of two healthy dietary patterns on physical and psychological symptoms

To study if it is feasible to conduct such a investigation in the future, I first want to search for 35 volunteers who are willing to follow the paleo diet during four weeks and the Dutch Consensus Diet during four weeks. After both periods of four…

A Single-Dose, Open-Label, Randomized, 4-Way Crossover Pivotal Study to Assess the Bioequivalence of Canagliflozin when Administered as the Monohydrate form to the Hemihydrate form in Healthy Adult Subjects under Fasted Conditions

The purpose of this studie is to evaluate the bioequivalence of canagliflozin.

Bioequivalence study of crushed Triumeq with or without drip feed compared to the whole tablet.

Primary objectives:To assess the bioequivalence of a single-dose TRI as a whole tablet (reference) compared to a crushed and suspended tablet (intervention I).To assess the bioequivalence of a single-dose TRI as a whole tablet (reference) compared…

Influence of over-the-wire micro-catheters on coronary haemodynamics and the accuracy of physiological indices for assessing the functional significance of intermediate coronary stenoses.

This study is designed to objectively document the physiological impact of a micro-catheter on coronary physiology parameters compared with a contemporary 0.014* sensor-equipped guide wire during both basal and hyperaemic conditions, and to identify…

Satiety related brain activation and gastric distention

To find the effects in satiety related brain regions and satiety related scores of additional gastric distention with similar nutrient load and oro-sensory exposure.

A randomized, double-blind, placebo-controlled, cross-over study to assess the effects of fampridine on eye movements and nerve conduction and function in patients with multiple sclerosis (MS) and a unilateral or bilateral internuclear ophthalmoplegia (INO)

Primary objective: - to evaluate the effects of fampridine on eye movements in MS patients with a unilateral or bilateral INO. Secondary objectives:- to determine whether there is an association between MRI signal of the medial longitudinal…

A double-blind, placebo controlled, randomised, parallel group study with an open-label cross-over part, investigating safety, tolerability, pharmacokinetics, and pharmacodynamics after single ascending oral doses and a single intravenous dose of the vasopressin V2-receptor agonist FE 202217

The purpose of the study is to investigate to what extent FE 202217 is tolerated. It will also be investigated how quickly and to what extent FE 202217 is absorbed and eliminated from the body (this is called pharmacokinetics). Also the effect on…

The use of a patellar strap in children with Osgood-Schlatter disease: a pilot study of the short term effect on symptoms and sports participation.

Primary objective:The purpose of this study is to evaluate the short term effect of a patellar strap on symptoms and sports participation in children with Osgood-Schlatter disease.Secondary objective: The second objective of this study is to…

A Phase I, single-center, open-label, randomized four-period, randomized five-period or randomized two period crossover study to investigate the pharmacokinetics of five different DMF-containing formulations of FP187 and the comparator products Tecfidera® and Fumaderm® in healthy volunteers after oral administration in fasted or fed state

Part IPrimary objectiveTo investigate the pharmacokinetics of the main metabolite of dimethyl fumarate (DMF) - monomethyl fumarate (MMF) - following administration of 3 different controlled release tablet formulations (FP187: V1, V2B, and V3B) and…

The Effect of Prehydration on the Pharmacokinetics of Low-dose Cisplatin

To determine if there is a difference in the pharmacokinetics of low-dose cisplatin with and without prehydration.

The Fear F8ctor Study

To explore the effects of acute fear on the coagulation system while sitting still.

A RANDOMIZED, TWO-PERIOD, OPEN-LABEL, SINGLE DOSE CROSSOVER STUDY TO EVALUATE THE BIOEQUIVALENCE OF AQX-1125 IMMEDIATE RELEASE TABLETS AND CAPSULES IN HEALTHY VOLUNTEERS

The purpose of the study is to investigate how quickly and to what extent AQX 1125 in the tablet form and the capsule form are absorbed and eliminated from the body (this is called pharmacokinetics). The pharmacokinetics of AXQ 1125 after…