148 results
Objective: The aim of the present study is to investigate whether additional titration on surface electromyography (EMG) of the diaphragm and intercostal muscles improves outcomes of chronic NIV in patients with COPD and stable CHRF in terms of…
The purpose of this study is to see if JNJ-42847922 is useful for treating patients with insomnia without any other psychiatric disease. The safety of JNJ-42847922 will also be studied.
The primary objective of this study is to investigate whether a protein mix is related to a faster postprandial amino acid bioavailability compared to a milk protein.
The primary objective of this study will investigate the effect of oral levosimendan on the respiratory function of patients with Amyotrophic Lateral Sclerosis.
The aim is to establish substantiated limit values based on the results of this study for tests used to determine driving ability in another study conducted with Cat. III drug users.
The objective of the study is to investigate the bioequivalence of 2 different proteins with regards to bioavailabillity in healthy elderly after one oral bolus intake.
To determine appetite responses to different odors (signalling different food products), measured by appetite questionnaires, a food preference task, saliva production and food intake
The objective of the study is to investigate the bioequivalence of Urd bioavailability in healthy elderly after bolus intake of oral UMP versus oral Urd.
Objective: To test the efficacy and safety of percutaneous renal sympathetic denervation of the native kidneys in the treatment of uncontrolled hypertension in kidney transplant recipients.
To test our hypothesis that:The combination of the two long-acting bronchodilators indacaterol and glycopyrronium confers a superior improvement compared to nebulisation with ipratropium/salbutamol, as administered single dose in patients with…
To investigate effect of tizanidine ER 12 mg on simulated driving performance, cognitive and psychomotor functions compared with placebo, tizanidine IR 8 mg (two 4 mg doses given 6.5 hours apart) and active-control in healthy subjects
Deulevodopa in combination with carbidopa is a combination in development for the treatment of patients with Parkinson*s disease.The effects of deulevodopa taken with carbidopa have not yet been tested in humans, and there are no available clinical…
The objectives of the study are as follows:Primary:• Part 1: To assess the pharmacokinetics and relative bioavailability of three different formulations of PA101 (4% cromolyn sodium with and without mannitol, and 6% cromolyn sodium without mannitol…
The principal aim of this study is to evaluate the PK parameters of both oral formulations in adult healthy volunteers in order to propose forMarketing Authorization Application an adequate strength for TETA•4HCl (i.e. a strength providing a PK…
To validate and compare smartphone-connected blood pressure monitors produced by Withings, Qardio and iHealth with the gold standard and a validated automatic blood pressure monitor.
The primary objective of this study is to evaluate the absolute bioavailability of an oral dose of 10 mg vericiguat (BAY 1021189) given as two 5 mg IR tablets following a high-fat, high calorie meal in comparison to a 14C labeled micro dose of…
Objective: The present study aims to investigate the effects of low glycogen availability on skeletal muscle molecular response after a concurrent exercise day.
To investigate whether uridine (Urd) area under the curve (AUC) and Cmax of product B is equivalent to the Urd AUC and Cmax of product A
To explore the effect of switching treatment from innovator infliximab (Remicade®) to infliximab biosimilar (Inflectra®, Remsima®) on efficacy, safety and immunogenicity in patients with rheumatoid arthritis (RA), spondyloarthritis (SpA) or…
We have developed a cueing application (app) for the Google Glass platform that can guide gait in PD-patients. Our initial observations showed that external cueing with the Google Glass application decreased the number and duration of FOG episodes…