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Potassium handling in chronic hemodialysis patients in response to higher dialysate potassium

To analyze how potassium handling, volume and sodium status change in stable anuric chronic hemodialysis patients (CKD-5D) in response to higher dialysate potassium.

A Phase 3, Multinational, Randomized, Placebo-Controlled Study of ARRY-371797 in Patients with Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation

In patients with symptomatic New York Heart Association (NYHA) Class II/III/IV dilated cardiomyopathy (DCM) in which mutations in the gene encoding the lamin A/C protein (LMNA) have been implicated:Primary Objective:* NYHA Class II/III patients only…

Functional electrical stimulation of the ankle dorsiflexors during walking in children with unilateral spastic cerebral palsy: a randomized crossover intervention study.

The primary objective of this study is to evaluate the effect of FES on participation level: achieving of individual goals, using the goal attainment scale (GAS)), and the Canadian Occupational Performance Measure (COPM) for the long term. Secondary…

Cyclic deep brain stimulation for obsessive-compulsive disorder

Our primary objective is to compare the effects of cyclic DBS with continuous DBS in OCD patients on 1) symptom severity. Secondary, we will compare the effects on 1) battery life 2) adverse events 3) cognitive performance 4) cortical EEG…

MAASFLEX: A Double-Blind, Randomized, Phase IV, Mechanistic, Placebo-Controlled, Cross-Over, Single-Center Study to Evaluate the Effects of 2 Weeks Dapagliflozin Treatment on Nocturnal Substrate Oxidation, Glucose Metabolism and Muscle Mitochondrial Function in Individuals with Impaired Glucose Homeostasis

The primary objective is to examine the effects of dapagliflozin on nocturnal substrate oxidation in overweight or obese subjects with disrupted glucose homeostasis but without T2D.