437 results
The primary objective of the study is to determine the gain in effectiveness of TE compared with P when applied to remove excess iron during maintenance therapy of HH patients.
The objective of this pivotal study is to assess the PK and PD as well as safety and tolerability of RP103 compared to Cystagon® in patients with nephropathic cystinosis. Results of this Phase 3 study will be used to support the registration…
Research question: Does oral administration with regulated release of 60 mg nifedipine a day reduce the symptoms of patients as determined in 1st. line health care, provided there is a good tolerancy of the medication.
Controlling the glycemic impact of food products may reduce glycemic and insulinemic responses. This may result in a decreased inhibition of fat oxidation rate and lower plasma TAG concentration. A higher postprandial fat oxidation may result in…
To characterize the glycaemic and insulinaemic responses of regular camel milk and camel milk powder in healthy adults.
Primary objective:To assess the puncture free survival after start of treatment with cediranib (time to first need for paracentesis or thoracentesis or time to death, which event occurred first)Secondary objectives:-To assess the palliative effects…
To investigate if there is a correlation between the peak GH concentrations after ingestion of gelatin protein and the peak GH concentrations after the two standard tests (GHST) in order to discriminate between GHD and non-GHD. To investigate the…
The primary objective of this study is to evaluate if there are differences in the tissue-interface pressures, pressures inside the tissues and tissue deformation in the sacral area when volunteers lie on a regular spineboard versus a vacuum…
Study 1:- Determine whether loss aversion behaviour (i.e. increased sensitivity to losses compared to gains) is modulated by dopamine levels using a pharmacological challenge- Assess whether this effect is accompanied by the modulation of brain…
Primary: Assessment of the short-term effect of a Heat and Moisture Exchanger on tracheal mucociliary clearance in laryngectomized individuals. Secondary: The relationship between clinical assessment, ciliary activity and mucociliary clearance.
Project 1: To investigate the neuroanatoimical correlates of attentional processing bias in nicotine addicts, using fMRI.Project 2: To examine whether attentional biases are dependent on dopaminergic transmission in the mesolimbic system using…
Our primary objective is to determine whether blocking IL-1β by recombinant human IL-1ra (anakinra) improves beta-cell function in subjects with β-cell dysfunction.
The objective of the study is to investigate the effect of PEEP ventilation with or without a recruitment maneuver on right ventricular afterload in infants undergoing cardiac surgery.
The primary objective of this study is to compare the stent migration rate of two metal expandable stents in patients with benign esophageal conditions.The secondary objectives are:• To compare the technical outcome.• To compare the functional…
Is a higher dose of aerosolised salbutamol as a treatment for preterm infants suspected for developing BPD more effective than a lower dose on short-term clinical effects?
to investigate whether showering shortly after Androgel application adversly affects plasma testosterone levels.
The purpose of this study is to investigate the acute effects of a single bout of WBV on spasticity of calf muscle in stroke patients.
To test if a new intervention, aimed at learning to use stop-rules in a flexible way(Stop Rule Management, SRM), has a more positive effect on the disability and quality of life of patient with non specific WREUP, than a regular rehabilitation…
To compare the burden for pregnant women and diagnostic capabilities of the oral glucose tolerance test (75g and 50g) and blood glucose samples during the day.
The primary objective is to show that energy expenditure of the body, during moderate physical activity on a bike ergometer, can become higher in response to high altitude simulation. The secondary objetive is to show that an increase in energy…