131 results
Primary objective:To assess the effect of multiple dose atorvastatin on the steady state pharmacokinetics of raltegravir and vice versa by intrasubject comparison in healthy subjects.• The comparison of steady state raltegravir (400 mg BID for 7…
: To investigate the overlap and differences in neurophysiological activity related to inhibition and orienting responses in the human brain.
The main objective of this study is to investigate whether radiofrequency electromagnetic radiation, induced by a mobile phone placed on the body, causes a change in electrophysiology.
Primary objective of the exploratory study is to assess whether the BOLD signal intensity of the hypothalamus changes after ingesting water and glucose solutions at different temperatures and with or without an added odorant.
The purpose of the study is to investigate how quickly and to what extent rivastigmine is absorbed and eliminated from the body when administered RTS for 7 days (this is called pharmacokinetics) as well as the safety of RTS.
Primary objective:To assess the BE under fasted conditions of BRV 10mg, 75mg, and 100mg oral tablets of commercial formulation vs BRV 50mg oral tablet(reference) of clinical development formulation,To assess the BA under fasted conditions of BRV…
To determine the direct effects of morning light intensity on postprandial glucose and lipid metabolism and metabolic gene expression in adipose tissue in obese subjects with and without type 2 diabetes.
To determine the influence of OATP1B inhibition, through rifampicin exposure, on the metabolism and plasma pharmacokinetics of sorafenib and its metabolites.
The primary objective of this study is to measure the effect of a psychopharmacological manipulation of NE on fMRI measures of the fidelity of cortical representation.The secondary objective is to determine if increased levels of cortical…
To examine the effect of an exercise-induced elevation of FFA on skeletal muscle lipid content. To this end, we compare skeletal muscle lipid content at baseline and after an exercise protocol and again after a four-hour recovery period from…
To assess the optimal target range of the automatic FiO2 function by maintaining the same mean, and narrowing the upper and lower limits of the target range.
To determine the relative bioavailability of ciprofloxacin oral suspension versus oral tablets in pediatric cancer patients, and to determine the absolute bioavailability of tablets and suspension utilizing the 100% bioavailability of intravenous…
The primary objectives of this study are (1) to assess how anticipatory reward related brain patterns differ from consummatory reward related brain patterns and (2) to assess how presentation of an anticipatory reward cue alters brain responses…
To assess the effect of amitriptyline on gastro-esophageal symptom severity and on esophageal sensitivity to acid perfusion and balloon distension in patients with documented functional heartburn.
The primary objective is to assess the relative bioavailability of TMC207 after single-dose administration of 100 mg of TMC207 as water dispersible tablets or granules using a 100-mg tablet formulation as the reference, with and without food.
The aim of this phase I study is to assess the extent of intestinal absorption of rivaroxaban and dabigatran etexilate in adult patients with short bowel syndrome and treated with long-term TPN.
The primary objectives are: 1) to determine the effect of bile acids on glucose uptake in brown adipose tissue; 2) to determine the effect of bile acids on whole body energy expenditure and 3) to determine the effect of bile acids on skeletal muscle…
This study has the primary aim to correlate subjective fitness of medical specialists to objective scales and relate the scores to validated levels of performance, which would be considered acceptable to perform surgical procedures.Objectives of…
To study the effect of 80 mg aspirin intake at bedtime compared with 80 mg aspirin intake on awakening on circadian rhythm of platelet function in healthy subjects.
To quantitatively determine the absorption and excretion of docetaxel (as ModraDoc005 10 mg tablets) after administration of a single low dose and a single high dose of oral docetaxel in combination with ritonavir.