145 results
The purpose of this study is to investigate how quickly and to what extent two 25 mg prolonged release tapentadol tablets are absorbed and eliminated from the body (this is called pharmacokinetics) when compared to one 50 mg prolonged release…
To evaluate the utility of the WATS system, as a potential substitute for the random sampling method that is currently recommended as an adjunct to targeted biopsy
The first goal of the present research proposal is to investigate whether single session COMET imagery procedures, relative to no intervention control, increase the ease of recollection, the specificity, vividness and positive affectivity of…
The objective of this study is to evaluate the acute effects of sitting on cognitive measures in healthy elderly, and if these effects can be prevented by breaking-up sitting and/or a high mental activity state. In addition, this research explores…
The aim of the current study is to compare the acute effect of nitrate supplementation. Therefore, we will assess the impact of concentrated beetroot juice, high nitrate vegetables versus nitrate depleted beetroot juice (placebo) on exercise…
To identify the role of dopamine transmission in the GC layer on motor learning in healthy individuals during cerebellar specific motor adaptation tasks.
The study will investigate auditory signal detection for voices or tones during and after anodal tDCS to the left STG, compared to stimulation of the left mPFC and sham stimulation. The experimental hypotheses are as follows:1) There will be a main…
Primary objective: To accurately assess the direct functional consequences of high versus low phenylalanine levels in adult patients with PKU, using eye-hand coordination testing in tasks of different cognitive complexity. Secondary objective: To…
The Primary objective is to confirm the maintenance of vigilance with SENS-111.Secondary objectives are:* to confirm the maintenance of working memory, and cognitive function; * to confirm the pharmacodynamics effect of SENS-111 on symptoms…
We hypothesize that the toxic potency of UFP from air traffic is comparable to road traffic after inhalation by healthy humans. Therefore, we aim to:* Identify acute effects of short-term inhalation of ultrafine particles right next to Amsterdam…
To develop a second VRelax prototype for reducing impact of stress and test it in patients with depressive, bipolar, anxiety and psychotic disorders. User experiences and immediate effects on subjective stress and arousal will be investigated and…
The present study explores the dose-response relationship in LSD-induced subjective and cognitive effects using small doses of LSD (5, 10, and 20 µg) compared to placebo.
The effect of a combination of orange- and pomegranate actives on physical fitness in elderly people
The primary objective of this study is to determine the effect of daily supplementation of a combined orange- and pomegranate extract for a period of 4 weeks on physical fitness compared to placebo.
Objective: To assess the degree of digestibility and protection of the epithelial barrier of two alternative protein concentrates from corn and bovine plasma and of the commonly consumed benchmark protein whey. These outcomes will also be used to…
The primary objective of the study is to prospectively confirm the safety and effectiveness profile of Coil treatment in consideration of the findings of previous Randomized Controlled Trials.Secondary objectives are determination of responder rates…
Primary objective:To evaluate the individual time-plasma concentration profiles of CBD following administration of three different chewing gum formulations.Secondary objective:To evaluate the safety and tolerability following administration of three…
The effect of pelvic floor physiotherapy with biofeedback in patients with anal fissure and pelvic floor dysfunction.
Primary Objective: Evaluation of effectiveness (AHI using PSG) of SPT when compared to MRA in patients with mild to moderate positional dependent obstructive sleep apnea (POSA) in a non-inferiority setting for a short (3 months) and longterm (12…
FT218 is a new formulation of the drug sodium oxybate (also known as the sodium salt of gamma-hydroxybutyric acid [GHB]), a registered drug under the tradename Xyrem® for the treatment of narcolepsy. FT218 has been administered to humans before.The…
To examine whether L-arabinose addition to a sucrose drink will lower glycaemic and insulinemic responses in people at increased risk of developing type II diabetes.