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Exercise Enhances

The purpose of our study is to test the augmenting effect and mechanisms of change of exercise provided directly before in total 12 CBT sessions.

The effect of arabinose on sucrose-induced glycemic response and glycemic kinetics as measured by a dual stable isotope methodology

To compare the digestion and absorption kinetics following the ingestion of sucrose plus arabinose versus sucrose only in healthy, young subjects.

The effect of citrus extract administration on markers of oxidative stress in elderly subjects

The aim of this study is to investigate the effect of citrus extract supplementation on markers of oxidative stress in elderly.

Predicting the effect of transcranial direct current stimulation on brain excitability

Primary Objective: To verify the main effect of TDCS on brain excitability and the interaction effects of BDNF genotype and APLM latency on this main effect. Secondary Objectives: Compare different prediction models for the main effect of TDCS in a…

The effects of soy on brain vascular function in elderly men and women

The primary objective of the current intervention trial is to evaluate in elderly men and women the effect of a 16-week soy treatment on gray matter cerebral blood flow, as quantified by the non-invasive gold standard magnetic resonance imaging (MRI…

A Phase 1, Open-Label Study to Assess the Relative Bioavailability, Effect of Food, and Gastric pH Modification on the Pharmacokinetics of TAK-931 in Patients with Advanced Solid Tumors

Primary Objectives:Part 1- Estimate the relative bioavailability of the tablet formulation of TAK-931 in reference to the PIC formulation.Part 2- Assess the effect of a high-fat meal on the single dose PK of TAK-931 administered as the tablet…

A randomized cross-over trial in the effect of automated oxygen control devices on the distribution of oxygen saturation in preterm infants

To compare the effect of two automated oxygen controllers (Oxygenie and CLiO2) on time spent within oxygen target range in preterm infants.

A double-blind, randomized, placebo-controlled, double-dummy, four-way crossover study to investigate the drug-drug interactions between ACT-541468 and ethanol in healthy subjects

To evaluate the pharmacodynamic (PD) effects of the study treatments (ACT-541468 50 mg, ethanol at a blood level of 0.6 g/L for 5 h) as co-administration in 4 different combinations (ACT-541468 plus ethanol, ACT-541468 alone, ethanol alone, and…

Self-initiated versus fully automated method for the measurement of blood pressure at home

The main goal is to assess the difference in average systolic bloodpressure between self-initiated and fully automated measurement, thereby evaluating the influence of the *auto-cuff* response in an out-of-office setting. Secondary goals are…

The effect of modulating hepatic glycogen content on hepatic fat oxidation

The primary objective of this study is to investigate to what extent hepatic fat oxidation can be stimulated by lowering hepatic glycogen content during a prolonged overnight fast. The secondary objective is to investigate whether reductions in…

A randomized, open-label, two-period, crossover study to determine the pharmacokinetics of reconstituted lyophilized Erelzi and Enbrel® (US-licensed) following a single subcutaneous injection in healthy male subjects.

The purpose of the study is to compare these two drugs in view of how quickly and to what extent the drugs are absorbed and eliminated from the body (this is called pharmacokinetics) after injection under the skin of the abdomen.In addition, it will…

Influence of macronutrient-related odours exposure on (congruent) appetite and actual food intake.
Cover story (for information brochure): Influence of odour exposure on alertness.

The primary objectives of the current study are to determine the influence of aware and actively smelled macronutrient-related odours on appetite, and actual food intake, in normal weight and unrestrained individuals.The secondary objectives of the…

Effect of the moderate CYP3A4-inhibitor erythromycin on the pharmacokinetics of palbociclib

The primary objective of this trial is to study the effect of the moderate CYP3A4 inhibitor erythromycin on the pharmacokinetics of palbociclib, measured as AUC0-24h, Cmax and Cmin.The secondary objective of this trial is to compare the incidence…

Randomized, double blind, placebo- and active comparator- controlled 3-way crossover study in healthy subjects to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of ENX-201

To assess PK of MPhs and MP.

Proof of concept clinical trial of safety and biological activity of Bifidobacterium Longum NCC 2705 in gluten sensitivity

The primary objective is to evaluate in the two targeted populations (i.e. CD and self-reported NCGS subjects):1) the safety profile of BL NCC 2705 2) the gastro-intestinal (GI) tolerability of BL NCC 2705

Open label, partially randomized, cross-over study to determine the absolute bioavailability
and pharmacokinetics of BAY 1817080 using a simultaneous anticipated therapeutic oral
dose along with an i.v. [13C715N]-labeled microtracer and to investigate the relative
bioavailability of two formulations given under different diets at 2 dose levels in healthy
volunteers.

The main purpose of this study is to investigate how quickly and to what extent BAY 1817080 is absorbed (taken up), distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). The pharmacokinetics of BAY…

Choline uptake study

The primary objective is determine choline uptake and bioavailability after consumption of a test drink with phospholipid-bound choline, and to compare this to a control drink with choline salt. Secondary objective is to compare the uptake and…

A Multi-cohort, Randomized Study in Healthy Subjects to Assess the Pharmacokinetics and Safety of Single and Multiple Ascending Doses of JNJ-61393215 (Suspension), and to Assess the Relative Bioavailability, and the Effect of Food on the Pharmacokinetics, of a New Solid Formulation (Capsules) of JNJ-61393215

This study will be performed in 56 healthy volunteers. The study will be performed in 3 parts, Part 1, Part 2 and Part 3. Part 1 will be performed in 16 healthy volunteers divided over 2 groups of 8 volunteers each. The purpose of Part 1 of the…

A single-center, randomized, double-blind, two-period cross-over study to investigate the effect of a single intravenous dose of rifampicin on the pharmacokinetics of ACT-246475 in healthy subjects.

The purpose of the study is to determine how a single administration of rifampicin influences the uptake and breakdown of ACT-246475. Furthermore, the safety and tolerability of ACT-246475 when administered after administration of rifampicin, will…

A single-dose, open label, randomized, three-way cross-over study in healthy volunteers to characterize the pharmacokinetics of the 300 mg trientine capsule and to assess the effect of dissolution rate and the effect of food on the pharmacokinetics of trientine.

Primary objectives:To characterize the pharmacokinetics of the 300 mg trientine capsule with a fast dissolution profile.To assess the effect of dissolution rate on the pharmacokinetics of trientine.To assess the effect of food on the…