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Multi-centre, randomized, investigator-blind, intra-individual active and vehicle-controlled study, comparing Metvix® Natural Daylight Photodynamic Therapy versus Metvix® conventional Photodynamic Therapy in subjects with actinic keratosis

Primary efficacy objective:To show the non-inferior efficacy of Metvix® Natural Day Light Photo Dynamic Therapy (NDL-PDT) versus Metvix® conventional Photo Dynamic Therapy (c-PDT) in Subjects with mild and moderate AKs at Week 12 in terms of percent…

Is CD35 Associated With Exudative Age-Related Macular Degeneration.

Is CD35, CD21, CD55 associated With Exudative Age-Related Macular Degeneration?

The influence of shock wave therapy on function improvement of upper limb muscles after stroke.

Authors hypothesized that the physical extracorporeal shock wave (ESW) stimulation will decrease the resting muscle activity of paralysed forearm muscles, reducing the degree of spasticity in surface electromyography examination as well as Modified…

Nifedipine induced pain relief during hysteroscopy

The relaxing effect of nifedipine on the uterus will cause pain relief during a hysteroscopy.

Microneedling after reconstructive scarring

30% improvement is the minimal effect found in previous microneedling studies, based on this studies we expect to find a 7.5 point improvement on the POSAS total score

Middle ear thiosulfate-gel protection against cisplatin-induced hearing loss in patients carrying a single nucleotide polymorphism in the TPMT, COMT or LRP2 gene

The primary objective of this study is to proof the concept that cisplatin-induced ototoxicity can be prevented by transtympanic STS containing gel application, through inserted grommets.The STS containing and blank gel formulations will be provided…

Single dose escalation study in a single center, randomized, single blind, placebo controlled, group comparison design to investigate pharmacokinetics, safety and tolerability of BAY 2253651 after intravenous administration in healthy male subjects.

The main purpose of this study is to investigate how quickly and to what extent BAY 2253651 is absorbed (taken up), distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). Multiple dose steps of BAY…

A two-part, single dose, randomized, single-blinded, placebo controlled, phase I study to assess the safety and pharmacokinetics of oral MT1980 in healthy volunteers when dosed in the fasted state

In this study we will investigate how safe the new compound MT1980 is and how well it is tolerated when it is used by healthy participants. We also investigate how quickly and to what extent MT1980 is absorbed, transported, and eliminated from the…

A study evaluating the pharmacokinetics, safety and tolerability of OP2113 administered intravenously in healthy volunteers and a marketed formulation administered orally

Primary objectives1. To evaluate the pharmacokinetic (PK) profile of the parent compound (anethole trithione, ATT) and its main metabolite (5-[4-hydroxyphenyl]-3H-1,2-dithiole-3-thione, ATX ) following administration of a range of doses of i.v.…