61 results
We aim to perform an in-depth investigation into the role of the mucosal immune response in the pathogenesis of rheumatoid arthritis. Our objectives are to study the presence of RA-specific autoantibodies and several other biomarkers (cytokines,…
Is there a difference in morphological and vascular placental development between ART and naturally conceived pregnancies?
To assess the safety and effect of edoxaban in Chil-Pugh B cirrhosis.
Research question: Is maternal microbiome dysbiosis in MOB an underlying mechanism in the pathophysiology of adverse maternal pregnancy and offspring outcome?Objectives: Analyse the differences between the gut and vaginal microbiome, maternal and…
The primary objective of this study is to assess wall shear stress in the left ventricle outflow tract using 4D flow CMR in healthy controls, asymptomatic HCM and before and after surgical myectomy in patients with HOCM,
The overall aim of the current study is to improve quality of life in patients with cognitive disorders. First, by improving diagnosis of PTSD symptoms in these patients. Second, we will estimate comorbidity rate of PTSD in clinical populations of…
Primary objective: Investigation of mean peak plantar pressure at the location of the diabetic foot ulcer and at 6 plantar regions of the foot (i.e. hallux, digits, first metatarsal, second to fifth metatarsals, midfoot, and heel) during total…
Primary Objective: to determine the activity rhythm of the SCN in humans with progressive stages of insulin resistanceSecondary Objective(s): to determine the daily rhythm of the peripheral clock in buccal cells in humans with progressive stages of…
Primary Objectives- To objectively quantify the spatial and temporal kinetics of perfusion and wound healing using clinical imaging and evaluations between diabetic wounds before and after endovascular revascularization and between diabetic patients…
The primary objective of this study is to study signs of small fiber neuropathy in PGAS patients compared to healthy controls.
The main aim is to study early neurocognitive functioning and development in very young children with SCD. The secondary aims are to identify determinants (risk and protective factors) and biomarkers of early neurocognitive deficits in SCD and to…
Objective: In this study we propose elucidating the pharmacokinetics of olanzapine in AN patients, to optimize the dosing strategy, to the extent of increasing the efficacy and reducing the risk of side effects. To this end, we will assess the…
To determine the prevalence of taste and smell dysfunction in patients more than two years after start of ICI therapy - compared with a control group of caregivers. Secondary objective: to assess the association between taste and smell dysfunction,…
(a) investigate long term functional outcomes of ADHD; *(b) identify factors that predict a favourable as well as non-favourable outcome/trajectory of ADHD;(c) investigate long term effects of the use of stimulants; in kaart te brengen.
In this clinical pilot study we want to gather data in order to calculate a power for correct subject group to answer the following research question: to explore the relation between NETs/cfDNA in the blood and NETosis in burn wounds and their…
The purpose of this study is to expand the so far limited research on the effectiveness of ImRs in the treatment of OCS. The primary objective is to investigate whether the application of ImRs, after previous outpatient ERP treatment, leads to…
This study aims to relate factors of hypercoagulability, inflammation or general illness itself (all during ICU admission) to microstructural and microvascular abnormalities on follow-up brain advanced 3T and 7T MRI in COVID-19 ICU survivors. By…
Primary ObjectiveIn order to assess the effects of anti TNFα on the development of adaptive and innate immunity, children exposed to anti TNFα (with or without other immunosuppressive drugs) will be compared to children exposed to immunosuppressive…
We aim to develop an innovative personalized prognostic model for outcome of children with TBI, using a unique combination of demographic, pre-injury and clinical predictors. The value of innovative MRI techniques and promising machine learning…
Alveolar cleft repair using osteoinductive ceramics in children with unilateral cleft lip and palate
To provide for evidence that calcium phosphate based scaffolds generate equal amounts of residual bone volume compared to the use of autologous bone grafts in unilateral alveolar cleft grafting. A secondary objective is to prove that calcium…