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Researching the Effects of Sepsis on Quality Of life, Vitality, Epigenome and gene expression during RecoverY from sepsis (REQOVERY)

To study the long-term changes in DNA methylation and gene expression in sepsis survivors and their association with long-term morbidity and mortality after sepsis.

Preterm Immune system development and response to Immunization

Primary objective is to study the antibody immune response to routine vaccinations in very preterm infants (GA<32 weeks). Secondary aim is to study the immune system more extensively using flow cytometry, ELISA and single cell transcriptomics…

Procalcitonin-guided treatment regarding antibiotic use for acute COPD exacerbations: a prospective randomised controlled trial

Our main aim is to develop a biomarker-based method to decide whether treatment with antibiotics is required for treatment of individual hospitalized AECOPD patients. We hypothesize that our biomarker-based intervention, using PCT levels to guide…

Evolution of mitochondrial dysfunction and hypermetabolic inflammatory status in septic Intensive Care Unit patients

The main objective is to investigate how mitochondrial function progresses over time in septic ICU patients. The secondary objective of the study is (a) to investigate how mitochondrial dynamics progress over time and how this is associated with…

Vaccinations in the Immunocompromised population: paramount and paradox.

The objective of this study is to determine the immune response after hepatitis A and pneumococcal vaccination in different groups of ICPs. The overarching aim of the study is to improve vaccine regimens and to optimize guideline recommendations…