26 results
* to describe the safety profile for qW, q2W and q3W regimens. * to determine the Maximum Tolerated Dose (MTD), if achieved (all regimens)* to describe the pharmacokinetics (PK) of single-agent RO6895882. Substudy BP28920/IMGThe study is designed to…
To study whether the pharmacokinetics of paclitaxel are influenced by scalp cooling
Currently, a 5-point mask and a standard headrest is used in the H&N patients. By replacing the standard headrest foran individual headrest that includes both the head, neck and part of the shoulders, it is expected that the translationsand…
Currently, a 5-point mask and a standard headrest is used in the H&N patients. By replacing the standard headrest for an individual headrest that includes both the head, neck and part of the shoulders, it is expected that the translations…
To evaluate the effect of chemotherapy on the serological and cellular immune response to influenza virus vaccination in patients with breast or colorectal cancer in order to establisch the optimal timing of vaccination during treatment with…
By means of this study we would like to answer the following questions:- Differs the humoral or cellular immune response after influenza vaccination between fatigued patients (with PCF or CFS) and non-fatigued patients?- Differs the humoral or…
1 To examine the differences in mindfulness between cancer patients and healthy references.2 To examine possible correlates of mindfulness, i.e. factors that may enhance or deplete mindfulness.3 To examine the relationship between mindfulness and…
This study will determine the concentration of benzo[a]pyrene before and after EVLA.
Accurately identify the molecular/ biochemical 'fingerprints' of the tissue structures and cell types within normal and malignant mucosa from the oral cavity, in particular the edge of the tongue and the floor of the mouth, based on Raman…
To investigate the state of the endothelial glycocalyx in cancer patients and determine the effect of chemotherapy on this layer.
The primary objective of this study is to establish the sensitivity and specificity of an oral uracil loading test as a potential screening tool for DPD deficiency
In our opinion, CTCs could serve as a pharmacodynamic marker to monitor anti-cancer therapy in clinical trials. Encouraging results, that show that CTCs have pharmacodynamic properties, were recently found in a prospective trial in which CTC number…
In this project the expression, glycosylation and sialylation of mucins will be determined in tissue specimens of salivary gland tumors and in parallel, in the saliva of patients with a salivary gland tumor to determine whether altered mucin…
Primary objective: To monitor levels of microparticles in response to a gift of chemotherapy on short term and in response to multiple gifts of chemotherapy. Secondary objective 1: To compare microparticle levels measured in blood acquired via a…
The main objective of this study is to examine the incidence of psychosocial needs, anxiety and depressive symptoms at each time point, and to identify risk factors for worse short-term Quality of Life (QOL) in lung cancer patients and their…
AimThe aim of this study is to determine if WMFA measured by DTI at 3T MRI in cancer survivors is a suitable biomarker in children between 8 -16 years of age for treatment induced neurotoxicity and related neurocognitive deficits.
Primary objectives: • To define any alterations in the oral and gut microbiome and metabolome in patients with HNSCC compared to healthy controls;• To investigate the dynamics oral and gut microbiome and metabolome in HNSCC before, during and after…
PRIMARY OBJECTIVE: -To assess the antibody response after mRNA (Pfizer, Moderna) SARS-CoV-2 vaccination in children with cancerSECONDARY OBJECTIVES:To assess in children with cancer after SARS-CoV 2 vaccination:- durability of the antibody response…
To obtain a fundamental understanding if and which chemotherapeutic agents used for treating cancer during pregnancy are associated with offspring (epi)genetic changes, potentially causing FGR and childhood/adult diseases later in life.