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Ovarian Ageing in type 1 Diabetes Mellitus: the role of vascular factors

To evaluate the prevalence of advanced ovarian ageing in cycling DM-1 patients using ovarian reserve (OR) testing. To assess the mean age at natural menopause and its variation in DM-1 patients. To study the role of vascular factors in relation to…

Study of menopause in ex-patients with Hodgkin lymphoma: Influence on long-term adverse effects

To examine the long-term effects of a CT- and/or RT-induced premature menopause on BMD, cardiovascular status, neurocognitive function and QoL in female HL survivors.

Favorable and unfavorable effects of risk-reducing salpingo-oophorectomy (RRSO) in women at high genetic risk of ovarian cancer

Primary Objective: To study long-term effects of premenopausal risk-reducing salpingo-oophorectomy (RRSO) on - cardiovascular status- bone mineral density- cognitionSecondary Objective: To study long-term effects of premenopausal RRSO on - quality…

Early TUbectomy with delayed oophorectomy to improve quality of life as alternative for risk reducing salpingo-oophorectomy in BRCA1/2 gene mutation carriers

To evaluate RRS after childbearing with delayed RRO as an alternative for RRSO in BRCA1/2 gene germline mutation carriers. We hypothesize that delay of menopause leads to an improvement of quality of life and sexual functioning, and a decrease in…

BRCA mutations and Ovarian ageing in women applying for in vitro fertilization and preimplantation genetiC diAgnosis

To demonstrate the presence of a reduced age specific ovarian reserve status in BRCA mutation carriers by:1. using serum AMH as ovarian reserve status test. 2. using the antral follicle count (AFC) as ovarian reserve test3. using ovarian response to…