18 results
Primary Objective: To measure cortical spreading depression with full-band EEG during the migraine attack at patients aged 4 years or older. Secondary Objective(s): -To explore (additional) signal analysis techniques for detecting CSDs or infra slow…
The focus of this present study will be to better understand the mechanism of ONS in MICCH. The primary objective of this study is to investigate the putative differences in rCBF at 6 months follow-up compared to baseline between responders of ONS…
1. To identify presymptomatic and symptomatic profiles including (early) disease stages and early biomarkers of disease progression and to elucidate pathophysiological mechanisms, we will investigate RVCL patients at different ages (both symptomatic…
ObjectivesOur main hypothesis is that ICP shows a dynamic profile over the course of different attack phases in migraine. Therefore, we aim to detect dynamic changes in ICP in relation to different phases of the migraine attack. In concreto, the…
- Measurement of the flow response to dermal application of capsaicin in the trigeminal nerve region in women with and without migraine.- Measurement of the flow response to dermal application of capsaicin in the trigeminal nerve region at various…
Objectivesi)) To study whether reproductive hormones play a role in migraine susceptibility in malemigraine patients; ii) to study functionality of the trigeminal system prospectively duringinterictal and premonitory phases of the migraine attack (…
Objectives- We want to study time-dependent activation in neuronal networks related to pain, vigilance and autonomic functioning in migraine patients during different migraine phases (including premonitory phase);- We want to correlate these changes…
1. To assess neuroimaging hallmarks of RVCL disease stages;2. To evaluate cerebrovascular reactivity as a biomarker of endothelial (dys)function in RVCL patients, in migraine patients and healthy controls;3. To identify shared pathophysiological…
In the present study we want to demonstrate progression of brain lesions and associated impairment of brain function in migraineurs vs. non-migraine controls. To this extent we have the following objectives:1) Measure progression of brain lesions of…
The objective of this study is to prove patients with CTTH and chronic neck pain after a whiplash injury have a lower nociceptive flexion reflex threshold compared to painfree controls.
1. To investigate the prevalence of an absent R1 component in migraine patients compared with healthy controls.2. Do headache characteristics differ between migraine patients with a R1 response and those without a R1 response ( Fast progressing vs…
Measuring difference in the conditioning between migraineurs and healthy volunteers, by using the eyeblinker.
Objectives- To study presence of (Cortical) Spreading Depression ((C)SD), using direct current (DC) EEG changes in migraine patients during different phases of the migraine attack;- Is there a change in DC-EEG recordings suggestive of (C)SD,…
The primary objective is to determine and compare the microvascular status between middle-aged women with and without migraine. Secondary objectives include a determination of the agreement and reproducibility of two devices which measure the blood…
The overall objective of this study is to combine a conceptual model with empirical evidence to demonstrate that the start of a migraine attack corresponds to a critical transition that occurs when the dynamical brain system approaches a tipping…
To compare free testosterone levels between male CCH patients and healthy controls Secondary Objectives: To compare differences in androstenedione, DHEA, DHT and 11oxC19 level, testosterone/estrogen ratio, activin level, inhibin level and morning…
To evaluate to what extent primary headache disorders are caused by genetic factors and to identify genes and pathways involved in the pathophysiology of these disorders.
The relationship with migraine is highly interesting and the main rationale for us to study the clinical characteristics of visual snow and its pathophysiology. Our hypothesis is that visual snow and migraine with aura are both disorders of cortical…