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Stimulation of the sphenopalatine ganglion with the ATI Neurostimulation system for cluster headache treatment

We investigated the safety and efficacy of on-demand SPG stimulation for chronic CH (CCH).

A study examining the pharmacodynamic interaction between buprenorphine and fentanyl

* To determine if buprenorphine action at the MOR receptor can inhibit the respiratory depression response to IV fentanyl injection in healthy subjects and patients with chronic opioid use;* To determine if therapeutic concentrations achieved with…

Directional Lead: Investigation of Rotational Current Steering, Ease of Use of Clinical Effects Map, and Therapeutic Outcomes of Deep Brain Stimulation

The primary objective is to characterize the programming effects of Boston Scientific Vercise* PC System using the Deep Brain Stimulation Directional Lead for bilateral subthalamic nucleus DBS for the treatment of Parkinson*s disease in acute and…

Liking of e-liquid flavors: correlation between smelling and vaping

Research on e-liquid flavors could be performed through smelling or tasting (*vaping*) experiments. The main objective of the Smell-e study is to determine if there is a correlation between liking of e-liquid flavors through smelling and liking of e…

Breitbarts* Meaning Centered Psychotherapy for MND patients: a pilot
study of an online psychological intervention.

It is our aim to adjust BMCP for MND patients with elevated levels of emotional distress. The intervention will be offered via Internet combined (blended) with face to face sessions. Further referred to as internet based BMCP (i-BMCP). Compared to…

A phase 1, randomized, observer-blind study to compare the safety, reactogenicity, and
Immunogenicity of Ad26.COV2.S at a single Dose of 5x10^10 vp in 2 different volumes in healthy adults

Ad26.COV2.S, also referred to as a *study vaccine* in this document, is a COVID 19 vaccine. In this study, the formation of antibodies against the coronavirus is compared at two different dosing volumes. In addition, it will be investigated if it is…

Optimizing treatment dosage for depression and comorbid personality disorders: a randomized clinical trial

In this study we will compare the (cost-) effectiveness on depression of 25- versus 50-sessions of psychotherapy (SPSP or ST) within one year in patients with depression and comorbid personality disorders. In addition we will examine the personality…

COGNITIVE BEHAVIOR THERAPY FOR TINNITUS RELATED INSOMNIA: A SINGLE-CASE EXPERIMENT

Primary Objective: This study aims to investigate the positive, negative or lack of effect that CBTi has on insomnia in tinnitus patients.Secondary Objective(s): Investigate the positive, negative or lack of effect that CBTi has on tinnitus…

EMDR protocol for urge to reduce scratching behaviour in prurigo nodularis

Primary Objective: To investigate if treatment according to the EMDR protocol for urge reduce daily scratching behaviour in PN patientsHypothesis: Treatment according to the EMDR protocol for urge leads to a statistically significant reduction of…

The impact of low level laser treatment on skeletal muscle and skin tissue mitochondrial respiration, metabolic activity and signaling in vivo in humans

Primary objective: To assess the impact of acute laser treatment on muscle tissue mitochondrial respiration in vivo in healthy, young adults. Secondary objective: To assess the impact of acute laser treatment on muscle cellular energy, anabolic,…