Search for a trial

A randomised controlled multicenter trial comparing ultrasound-accelerated catheter-directed thrombolysis combined with standard anticoagulant therapy versus standard anticoagulant therapy alone for acute primary iliofemoral deep vein thrombosis (IFDVT).

Primary Objective: Can catheter directed thrombolytic therapy, for the treatment of primary IFDVT, safely and effectively reduce post thrombotic morbidity after one year?Secondary Objective: Does catheter directed thrombolytic intervention have a…

Joint distraction as a treatment for end stage knee osteoarthritis: a comparison with presently applied surgical alternatives.

1. Is KJD clinically non-inferior to current surgical techniques (HTO and TKP)?2. Is KJD superior to HTO in actual structural repair of cartilage?3. Is KJD cost-effective in the long-term compared to HTO and TKP?

Acceptance and Commitment Therapy as a self-help intervention for adults with mild to moderate psychological distress: a randomized controlled trial

The purpose of the study is to conduct a randomized controlled trial with the self-help intervention *Voluit leven* for adults with mild to moderate psychological distress. The research question is: What are the effects of the preventive self-help…

Effect of high-frequency chest wall oscillation and manual hyperinflation on the resolution of atelectasis in ventilated patients

Studies provide statistically significant evidence of the effectiveness of high-frequency chest wall oscillation administered via The Vest* System.St. Elisabeth Ziekenhuis Tilburg wants to demonstrate the effectiveness of HFCWO on ventilator-…

Is the hypothalamic neural activity disturbed in patients with familial combined hyperlipidemia?

1. To evaluate whether patients with FCH have different pattern of hypothalamic neural activity compared to healthy control subjects, 2. To evaluate whether patients with FCH (index patients) have a different pattern of hypothalamic neural activity…

Antiplatelet therapy in combination with Recombinant t-PA Thrombolysis in Ischemic Stroke

The objective of this trial is to investigate whether adding acute APT to rt-PA thrombolysis in ischemic stroke reduces death or dependency at 3 months.

A randomized, double masked, active controlled, phase 3 study of the efficacy, safety, and tolerability of repeated doses of intravitrial VEGF Trap-Eye in subjects with neovascular age-related macular degeneration (AMD)

Primary objectiveTo assess the efficacy of intravitreally (ITV) administered VEGF Trap-Eye compared to ranibizumab (in a non-inferiority paradigm) in preventing moderate vision loss in subjects with all subtypes of neovascular AMD Secondary…

The pitfall of active inflammation during surveillance colonoscopy in inflammatory bowel disease patients

The overall objective is to assess the effectiveness of treating patients with corticosteroids prior to surveillance in order to diminish the pitfall of active inflammation.

Continuation of Metformin during surgery in patients with diabetes mellitus type 2

The objective of the study is to investigate the glucose lowering potential and safety of continuation of Metformin during non-cardiac surgery, compared to discontinuation of Metformin 24 hours before surgery.

YP Face IT: Assessing the feasibility, acceptability and potential effectiveness of an online psychotherapeutic intervention for adolescents with visible differences that suffer from appearance related problems.

This is the first project in The Netherlands aimed at testing the acceptability, feasability and effectivity of an online intervention aimed at the psychosocial functioning of adolescents with a visible difference. The aim is to 1) test if the…

Difference in Patient Reported Outcomes at 1 year after 6 or 8 weeks of carpometacarpal joint distraction: a Randomized Controlled Non-Inferiority Trial.

Primary Hypothesis: - There is a difference in PROMIS Physical Function Upper Extremity Short Form (PROMIS PF UE SF) score between group A (6 weeks distraction) and group B (8 weeks distraction) at 1 year after first carpometacarpal joint…

Determining the causative agent and optimal duration of antibiotic therapy in persons with diabetes and foot osteomyelitis: BonE BiOPsy (BeBoP) trial

Primary Objective: To prospectively compare outcomes of subjects with diabetic foot osteomyelitis treated with antibiotics targeted at culture results from bone biopsy (intervention group) versus therapy targeted at ulcer bed biopsy culture results…

Discontinuation of ANtihypertensive Treatment in Older people with dementia living in a Nursing home

To assess whether discontinuation of antihypertensive treatment in nursing home residents with dementia a) reduces NPS and improves quality of life; b) improves general daily functioning and cognitive functioning; c) reduces psychotropic medication…