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Late Effects and Follow up after pediatric hematological stem cell transplantation and cell therapy (LEEF)

Better knowledge and awareness of Late Effects after pediatric HSCT for non-malignant diseases will lead to optimal screening procedures after HSCT that may eventually contribute to reduce transplant-related long term morbidity and mortality and…

A phase III Prospective Externally Controlled Non-Inferiority Cohort Trial to Compare the Efficacy of Re-Irradiation Schedules in Glioma (RISinG)

To determine if re-irradiation in 4 fractions is non-inferior to 10 fractions in the primary endpoint of survival after re-irradiation. Secondary objectives are to establish and compare health related quality of life (HRQoL), recurrence patterns,…

The importance of early brain changes in patients with MS with regard to cognitive and physical outcome

The main objective of this project is to identify the early brain changes in MS (i.e. patients that are recently diagnosed with MS) that can be measured by advanced structural and functional (network) imaging measures. Additionally, we will…

The oropharyngeal microbiome and metabolome as potential novel biomarker for disease progression or treatment response in head and neck squamous cell carcinoma (HNSCC); a pilot study.

Primary objectives: • To define any alterations in the oral and gut microbiome and metabolome in patients with HNSCC compared to healthy controls;• To investigate the dynamics oral and gut microbiome and metabolome in HNSCC before, during and after…

Rac1/pSTAT3 expression: a potential pharmacodynamic marker to optimize and individualize thiopurine therapy in IBD patients

The aim of this study is to explore differences in expression of Rac1 and pSTAT3 in leucocytes of therapy-naïve IBD patients, IBD patients on immune suppressive therapy and healthy controls.

Wheels lifestyle intervention study.

Primary objective:Does the use of the application support a positive lifestyle development?Secondary objectives:Does the use of the application support an increase in physical activity levels?Does the use of the application has a positive influence…

Visual function recovery in patients after foveal splitting rhegmatogenous retinal detachment

To investigate visual function recovery after surgery for foveal splitting RRD.

LANDMARK Trial: A prospective, multinational, multicentre, open-label, randomised, noninferiority
trial to compare safety and effectiveness of Meril*s Myval Transcatheter Heart Valve
(THV) series vs. Contemporary Valves (Edwards* Sapien THV series and Medtronic*s Evolut
THV series) in patients with severe symptomatic native aortic valve stenosis.

LANDMARK Trial is designed to compare safety and effectiveness of Meril*s Myval Transcatheter Heart Valve (THV) series vs. Contemporary Valves (Edwards* Sapien THV series and Medtronic*s Evolut THV series) in patients with severe symptomatic native…