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Unravelling aetiology and risk factors in patients with a Bicuspid Aortic Valves * study of clinical outcome and genetics

The BAV study is a clinical and genetic study to unravel biomarker and imaging predictors of adverse outcome and to explore the pathogenetic basis of bicuspid aortic valves and it*s associated pathologies. We will also deliver insights in the…

Unravelling intestinal inflammation: from Celiac Disease genotype to autoimmunity.

The primary aim of the current proposal is to get a better understanding of how CeD risk genes contribute to disease aetiology. To achieve this, we will apply a holistic approach in which we will study the behaviour of immune cells and the…

Understanding Q-detect: Coxiella burnetii exposure and the humoral and cellular immune response

(i) to determine specificity of Q-detect* for registration purposes. (ii) to design a decision tree for follow-up of patients with a positive Q-detect* and

Human induced pluripotent stem cells to unravel the pathophysiology of peripartum cardiomyopathy

Employing PPCM patient-derived iPSCs, we aim to test our hypothesis that cardiomyocytes from PPCM patients exhibit (epi)genetically determined differences in protein expression profiles and functional behavior in comparison to those from healthy…

The Heart And NeuroDevelopment study - Development of the brain in fetuses and children with severe congenital heart disease

To establish benchmark values in healthy control fetuses, to compare these with our cohort of fetuses with severe CHD.