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An fMRI and EEG study in patients with mild to moderate Alzheimer*s disease and healthy elderly controls

1. To determine the feasibility of performing a few functional magnetic resonance imaging (fMRI) tasks and clinical neurophysiological measurements in patients with mild to moderate AD.2. To validate the visual perception fMRI task in healthy…

An exploratory study to biotype adult patients with unipolar depression using digital technologies

Primary Objectives* To characterize patients with unipolar depression in terms of social, physical, biometric activity, and neurophysiological and -psychological data outcomes using digital technologies * Evaluating the feasibility and subjective…

New syndromes in old genes; phenotypes caused by CREBBP and EP300 mutations but not resembling Rubinstein-Taybi syndrome

To gain insight into the biological pathways that are influenced by the CEEx30/31 mutations.

Detection of perifoveal microvascular changes in Behçet Disease measured with OCT-A

To compare, the perifoveal microvascular changes (non-perfusion areas) in the deep capillary plexus layer between Behçet patients with and without ocular involvement and control subjects, using OCT-A.

Are circulating hematopoietic stem and progenitor cells a potential biomarker for therapy response and disease progression in patients with squamous cell carcinoma of the head and neck?

We hypothesize that the cytokines secreted by HNSCC may perturb the hematopoiesis in patients. We wonder whether this perturbation can be restored after local treatment of the tumor.Primary objective: In this pilot study, we aim to prospectively…

Expression of hSPCA1 and ultrastructural analysis of the skin before and after laser therapy in Hailey-Hailey disease

We aim to (1) study the expression of hSPCA1 in keratinocytes before and after laser therapy and (2) verify the loss of acantholysis by immunohistochemistry and electron microscopy of cell-cell adhesions before and after laser therapy.