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Abnormal sex hormone exposure of the brain; possible neuroendocrine implications for cognition in adult transsexuals and women with polycystic ovarian syndrome as clinical models

The overall aim of the present work is to evaluate the individual role of androgens and estrogens on brain function in the human with a focus on cognition. Both clinical models give us the opportunity to evaluate cognitive functions and brain…

The Effect of Gaucher Disease on Bone Cells

This will be a pilot study that aims to gain insight into the effect of Gaucher disease on bone metabolism. For this purpose we formulated the following research questions:What is the effect of inflammatory factors in the serum of patients with…

Is the presence and development of microvascular disease in type 1 diabetes related to changes in brain structure and cognitive function?

To answer the question if structural changes of the brain and impairments of cognitive functioning in type 1 diabetes are related to the presence of microvascular disease we will· Compare brain structure (brain volume, white matter lesions) and…

Decoding words with 7 Tesla functional MRI

The overall goal of this study is to assess the detection and discrimination of individual silently or attempted spoken words from the brain area that represents articulation of speech.To address this goal, we defined three primary objectives:1) To…

Communication in context in neurotypical and ASD populations

We aim to provide a neurocognitive account of communicative disabilities in patients with autism spectrum disorder (ASD), focussing on shared representations of a communicative context. We expect that ASD patients show impaired shared…

Glucose transport and mitochondrial function in type 1 diabetes mellitus

Primary Aim: We aim to determine markers for NOX2-mediated insulin-independent glucose uptake signalling pathways, mitochondrial function, myokine secretion both at rest and after a bout of acute exercise in individuals with T1DM and healthy…

CALCification as an early marker of vasculopathy and organ involvement in Systemic Sclerosis

1. To assess serum calcification propensity (T50) in SSc patients compared with healthy age and gender-matched controls; 2. To assess serum T50 in SSc patients with overt calcinosis cutis as compared to age and gender-matched SSc patients without; 3…

Language, speech and motor function in mild cognitive impairment due to AD and Alzheimer*s disease

Primary objective: To determine the characteristics of language, speech and motor functions in MCI due to AD, mild AD and moderate AD Secondary objective: To explore the association between language, speech and motor functions in MCI due to AD and…

Exercise as a countermeasure against the effects of ageing on muscle mitochondria, diffusive oxygen transport and muscle volume

The primary aims of this study are therefore to 1) compare DmO2 derived via NIRS between young sedentary, young endurance-trained, older sedentary, and older endurance-trained subjects; 2) to compare non-invasive (i.e. with NIRS and 31phosphorous…