36 results
Identifying the genotype-phenotype-imaging correlates in GBA mutation carriers with and without Parkinson*s disease using functional and structural magnetic resonance imaging (MRI).
a) To evaluate whether PAPP-A2 and inhibin A could be used as biomarkers for preeclampsia and preeclampsia-related outcome in twin pregnancies. To achieve this objective, we will first assess:- Whether PAPP-A2 and inhibin A levels are increased in…
Primary questionAre changes in vigilance in type 1 and 2 narcolepsy, idiopathic hypersomnia and epilepsy with only nocturnal seizures reflected in differences in the responsiveness of the pupils to light as measured by pupillometry (PIPR) versus…
Objective: Since the inflammatory reaction plays an important role in wound healing problems and scar formation the main goal of this project is to unravel different inflammatory mechanisms involved. • Explore relationships between local and…
To determine ex vivo neutrophil functions following exposure to therapeutic antibodies targeting inhibitory receptors expressed by neutrophils from RSV bronchiolitis patients. A secondary aim is to study soluble inhibitory receptors (such as LAIR-1…
The aim of this study is to investigate how many patients with an early and/or chronic psychotic disorder reach personal recovery during follow-up and which determinants and processes influence personal, clinical, functional and societal recovery…
To obtain sex-specific biomarkers, based on pathogenesis of microvascular disease, that improve the early diagnosis of diastolic dysfunction and HFPEF. These biomarkers come from innovative sources such as circulating endothelial cells,…
Our objective is to find predictive biomarkers for disease progression in RVCL-S, a monogenetic small vessel disease, and to dissect disease mechanism to identify new treatment targets to improve health for RVCL-S patients, which may also serve as…
The primary aim is to determine whether the relative aerobic load of walking is a determinant of the amount of walking in daily life in people with a chronic spinal cord injury with a walking function. Secondary goals are to gain insight into other…
To study the neuroplasticity of the brain due to facial synkinesis by assessing the somatotopy of the face on several cortexes of interest (primary and secondary somatosensory cortexes, the primary motor cortex, the supplementary motor cortex, the…
This study aims to achieve 4 goals: (1) to identify the brain network involved in mediating the effects of cueing as an important compensation strategy; (2) to identify differences in brain connectivity patterns elicited by internal versus external…
The primary objective is to explore the urine microbiome (urobiome) composition of postmenopausal women with and without RUTI at five scheduled time points during one year of follow-up, as well as before, during, and after UTI episodes when they…
To compare serum estradiol levels during the late luteal phase between 1) women with menstrually-related or pure menstrual migraine and premenopausal controls and 2) perimenopausal migraine patients and perimenopausal controls. Secondary objectives…
Primary objective: To identify rare, high impact genetic variants in immunological genes and pathways in children with a history of MIS-C or pediatric post-COVID condition. Secondary objectives: To analyze the clinical characteristics and long-term…
Primary Objective: 1. Objectify and quantify exercise intolerance in LcFAOD patients. 2. Determine the relationship between the measured exercise intolerance and patient-reported symptoms, daily life functioning , as well as known markers of disease…
The main objective of CRUCIAL-VCI is to determine a surrogate MRI marker for microvascular density in patients with VCI due to cSVD, and to relate this to disease severity expressed as macrostructural brain damage and cognitive function. The…
To identify genetic variants for the development and progression of keratoconus using Whole Exome Sequencing and Whole Genome Sequencing approaches on keratoconus families with index patients originating from the Rotterdam Eye Hospital and Erasmus…
Primary objective:1. To assess the effect of 4 weeks SXB treatment on basal and cold-induced WAT lipolysis (assessed by levels of circulating free fatty acids) in narcolepsy type 1 patients. Secondary objectives:1. To assess the effects of 4 weeks…
The primary objective is to characterise and understand the heterogeneity in patients with ME/CFS (i.e. comorbidities, variability in symptoms and disease progression, severity, and cognitive and autonomic impairment). Therefore, the secondary…
to characterize the endometrial immune environment in patients with SLE