25 results
Is there a difference in morphological and vascular placental development between ART and naturally conceived pregnancies?
Our primary objective is to assess the postprandial anabolic response to mixed meal testing in both young and elderly, healthy volunteers. Our secondary objectives are to assess the effect of MMT on glucoregulatory and gut hormones, lipid profiles,…
(a) investigate long term functional outcomes of ADHD; *(b) identify factors that predict a favourable as well as non-favourable outcome/trajectory of ADHD;(c) investigate long term effects of the use of stimulants; in kaart te brengen.
Primary Objective: to determine the activity rhythm of the SCN in humans with progressive stages of insulin resistanceSecondary Objective(s): to determine the daily rhythm of the peripheral clock in buccal cells in humans with progressive stages of…
We aim to perform an in-depth investigation into the role of the mucosal immune response in the pathogenesis of rheumatoid arthritis. Our objectives are to study the presence of RA-specific autoantibodies and several other biomarkers (cytokines,…
Research question: Is maternal microbiome dysbiosis in MOB an underlying mechanism in the pathophysiology of adverse maternal pregnancy and offspring outcome?Objectives: Analyse the differences between the gut and vaginal microbiome, maternal and…
The main aim is to study early neurocognitive functioning and development in very young children with SCD. The secondary aims are to identify determinants (risk and protective factors) and biomarkers of early neurocognitive deficits in SCD and to…
This study aims to relate factors of hypercoagulability, inflammation or general illness itself (all during ICU admission) to microstructural and microvascular abnormalities on follow-up brain advanced 3T and 7T MRI in COVID-19 ICU survivors. By…
We aim to develop an innovative personalized prognostic model for outcome of children with TBI, using a unique combination of demographic, pre-injury and clinical predictors. The value of innovative MRI techniques and promising machine learning…
Is moderate exercise training for 12 weeks in women with RPL improving CD56bright eNK cell population and function?
The aim of this longitudinal study is to find new biological, clinical and/or electrophysiological biomarkers in order to define and differentiate individual diagnoses of NT1 and the NBL, and to find improved treatment targets and strategies.
- To assess platelet (dys)function in adults with 22q11.2DS and its association with bleeding history.- To identify alterations in metabolic pathways in 22q11.2DS that may be of relevance to mechanisms underlying neurodevelopmental and…
To assess the effects of anesthetics on local (cerebral) microvascular parameters in craniotomy patients. Secondary objective: To assess the effects of anesthetics on systemic (sublingual) microvascular parameters in craniotomy patients.
The aims of this study are:1. To describe the neuropsychiatric profiles associated with DDX3X syndrome, SETD1A syndrome, Koolen-De Vries syndrome, KBG syndrome, DYRK1A syndrome, Jansen-De Vries syndrome, Gabriele-De Vries syndrome, and Smith-Magenis…
Primary objective: To longitudinally characterize alterations in electrophysiological biomarkers in ALS of peripheral excitability in relation to neurodegeneration. Secundary objectives:1. To determine the value of multi-muscle CMAP-scan outcomes as…
The main study objective is to investigate differences in the dopaminergic and serotonergic systems between adults with alcohol use disorder (AUD) and co-occurring internalizing (e.g. depression) or externalizing (e.g. ADHD) mental disorders; and…
The primary goal of this study is to identify immunological alterations in blood, lymphoid tissue, bone marrow and muscle in IIM patients. Furthermore, our objective is to specifically profile autoreactive B lineage cells from IIM patients isolated…
The primary objective is to identify clinical and biological measures that discriminate paediatric ME/CFS and post-COVID patients from healthy controls based on either clinical (based on physiological tests and questionnaires) and biological (based…
To assess the transcriptional, epigenetic and functional reprogramming of circulating and tissue (BM and spleen) monocytes and myeloid progenitor cells in the context of ovarian cancer.
We aim to develop a personalized multi-scale biomechanical model of the knee that integrates joint movement (marker-based motion capture, fluoroscopy), EMG and force data with quantitative cartilage parameters derived from advanced imaging…