43 results
The aim of this study is to determine whether multiparametric MRI (mpMRI) of the bladder, in combination with an outpatient biopsy for histological confirmation, is a faster, safer, cheaper and therefore more cost-effective way to detect or…
Primary objective:1) To determine the discriminating ability of the microvasculature between uteri with adenomyosis, myomas and no uterine disorders. Secondary Objectives: 2) To determine the discriminating ability of the microvasculature between…
To assess the effects of anesthetics on local (cerebral) microvascular parameters in craniotomy patients. Secondary objective: To assess the effects of anesthetics on systemic (sublingual) microvascular parameters in craniotomy patients.
The primary objective of this study in people with PD is to examine the clinical feasibility, in terms of safety, adherence, performance and user experience (i.e., patient and physiotherapist), and effectiveness of home-based gamified cueing-…
The primary objective of this study is to evaluate the (cost-)effectiveness of ET for late-life anxiety disorders delivered by trained MHNs in primary care, in terms of anxiety and quality of life, compared to UC. UC is not restricted, and the GP…
The primary aim of the proposed study is to evaluate the effectiveness (1) and cost-effectiveness (2) of a DST for patients with anxiety and/or mood disorders in comparison to UC.The secondary aims are: 3) to identify what works for whom by…
Primary Objective: Assess the effect of mental imagery with fMRI-neurofeedback-based upregulation of the putamen on motor symptoms of PD Secondary Objective(s): -Assess changes in whole brain activation patterns over the course of the NF training -…
The primary objective of this study is to evaluate the efficacy of the AtMoves Knee System in the clinical diagnostic process of aseptic knee loosening in knee prostheses. This will be measured by the number of *failed outcomes* resulting from…
Primary Objectives:Associated pharmaceutical trial:To compare the efficacy of disitamab vedotin in combination with pembrolizumab to chemotherapy as first-line treatment in participants with advanced UC that expresses HER2Clinical…
The primary objective is to determine whether implementation of a best-practice protocol focused on antimicrobial stewardship in Dutch hospitals is non-inferior compared to standard care on mortality and major complications in patients with acute…
The aims of this study are:1. To describe the neuropsychiatric profiles associated with DDX3X syndrome, SETD1A syndrome, Koolen-De Vries syndrome, KBG syndrome, DYRK1A syndrome, Jansen-De Vries syndrome, Gabriele-De Vries syndrome, and Smith-Magenis…
To ascertain differences in mitochondrial and microcirculatory parameters between healthy older adults (> 65 years and ASA1-2) and more vulnerable elderly patients (> 65 years and ASA 3-4).
Primary objective: describe the longitudinal changes of Aβ38, Aβ40, Aβ42, and Aβ43 concentrations in CSF of patients with CAA, AD, and healthy control cases and estimate the differences in change between those groups.1. Explorative study to…
To obtain the best filling pressure of the Pes catheter in spontaneous mechanical ventilation, to obtain the esophagus elastance in spontaneous mechanical ventilation, and to compare the best filling pressures between the two modes (spontaneous and…
The objective of this pilot study is to evaluate the effects of separate individualization of the AFO stiffness towards plantar- and dorsiflexion in a spring-hinged NEURO SWING AFO compared to a spring-like AFO without hinge (3 types) having the…
The aim of this study is to assess the position and alignment of the Atlas, as measured by the angles between the atlas and the surrounding vertebrae in healthy participants, patients with tension headache, and patients with chronic whiplash-…
To evaluate the degree of osteoarthritis 5 to 10 years after a hip arthroscopy in comparison with the non-operative side.
Unravelling the *measles paradox* by in-depth characterization of the immune repertoire before and after natural measles or measles vaccination.
To identify if, how and when VR is of added value in current treatment methods for people with SAD and MBID.
The general aim of this project is to determine the (cost-)effectiveness of footwear modification in addition to GP-led usual care, compared to GP-led usual care alone for patients with first MTP joint osteoarthritis (OA) at 6 months of follow-up…