43 results
The aim of this study is to determine whether multiparametric MRI (mpMRI) of the bladder, in combination with an outpatient biopsy for histological confirmation, is a faster, safer, cheaper and therefore more cost-effective way to detect or…
To identify if, how and when VR is of added value in current treatment methods for people with SAD and MBID.
The objective is to improve the understanding of intracochlear electrocochleography for objective measurement of residual hearing. ECochG responses obtained postoperatively in patients with different aetiologies will be evaluated in…
To ascertain differences in mitochondrial and microcirculatory parameters between healthy older adults (> 65 years and ASA1-2) and more vulnerable elderly patients (> 65 years and ASA 3-4).
The aims of this study are:1. To describe the neuropsychiatric profiles associated with DDX3X syndrome, SETD1A syndrome, Koolen-De Vries syndrome, KBG syndrome, DYRK1A syndrome, Jansen-De Vries syndrome, Gabriele-De Vries syndrome, and Smith-Magenis…
The iBerry Study has two main study objectives:1. Descibing long-term prognosis of subclinical symptoms in terms of course (transition to several psychiatric disorders, chronicity, recurrence, comorbidiy) and public health consequences (disability,…
The primary objective of this study is to evaluate the (cost-)effectiveness of ET for late-life anxiety disorders delivered by trained MHNs in primary care, in terms of anxiety and quality of life, compared to UC. UC is not restricted, and the GP…
The primary aim of the proposed study is to evaluate the effectiveness (1) and cost-effectiveness (2) of a DST for patients with anxiety and/or mood disorders in comparison to UC.The secondary aims are: 3) to identify what works for whom by…
Primary Objective: Assess the effect of mental imagery with fMRI-neurofeedback-based upregulation of the putamen on motor symptoms of PD Secondary Objective(s): -Assess changes in whole brain activation patterns over the course of the NF training -…
To assess the transcriptional, epigenetic and functional reprogramming of circulating and tissue (BM and spleen) monocytes and myeloid progenitor cells in the context of ovarian cancer.
The main objective is to explore whether digital features of dysarthria, dysphonia, proximal arm fatigue and ptosis can differentiate between participants with and without MG.
The purpose of the pivotal study is to determine the safety and efficacy of IMPEDE-FX RapidFill for increasing the percentage of subjects with shrinkage of the abdominal aortic aneurysm sac when used as an adjunct to on-label EVAR stent graft…
We aim to develop a personalized multi-scale biomechanical model of the knee that integrates joint movement (marker-based motion capture, fluoroscopy), EMG and force data with quantitative cartilage parameters derived from advanced imaging…
Our primary objective is to compare neuroimaging markers on a 3T MRI-scan with the MRI-scans that were performed during TRACK-HD in 2008-2011. We will assess the following neuroimaging markers, starting with the most important marker: 1. Structural…
The overarching aim of this study is to develop new, sensitive measures for aspects of social cognition (emotion experience, empathy and affective theory of mind), that will contribute to a better and earlier diagnosis of specific subtypes (the…
Primary objective:1) To determine the discriminating ability of the microvasculature between uteri with adenomyosis, myomas and no uterine disorders. Secondary Objectives: 2) To determine the discriminating ability of the microvasculature between…
To assess the effects of anesthetics on local (cerebral) microvascular parameters in craniotomy patients. Secondary objective: To assess the effects of anesthetics on systemic (sublingual) microvascular parameters in craniotomy patients.
To explore the pathophysiology of post-exertional malaise (PEM). Investigate the changes occurring in cardiovascular parameters, cognitive capacity, physical capacities, brain activation and perfusion, and metabolites in patients with ME/CFS…
Identifying the (immune) cell composition, co-localization, functions, and alterations as well as blood and lymph vessels reorganisation in the human*s dura, arachnoid and pia mater, and skull bone marrow in high-grade glioma patients as compared to…
The overarching objective of this master protocol is to study the risk factors (personal, clinical and lifestyle factors) for-, and consequences of- , changes of nutritional status (both over- and undernutrition) in children with cancer. Based on…