14 results
The primary objective for this study is to evaluate the cerebrovascular reactivity of HCHWA-D patients:1. To compare the (autoregulatory) function of small brain vessels in HCHWA-D patients with matched controls using the cerebrovascular reactivity…
The general aim of this study is to implement validated markers for CAA in asymptomatic individuals with CMBs, to investigate whether presence of CMBs signifies early CAA.
The main object is to evaluate the validity of a diagnostic screening package for bleeding tendency consisting of point-of-care devices when compared with the gold standard for bleeding tendency diagnosis.Other objects which will be investigated are…
The overall aim of this study is to investigate the pathophysiology of ICH by investigating intracerebral hemorrhage in HCHWA-D patients. By investigating triggers for ICH, hematoma expansion, recurrence rate and outcome in HCHWA-D related ICH we…
Primary Objective: 1) To charaterize microbleeds and microinfarcts at 7T, and compare their prevalence in people with and without diabetes, with or without cognitive impairmentSecondary Objective(s): 2) To assess the relevance of the lesions in the…
Primary Objective: 1) To compare the prevalence en number of microbleeds at 7T between older people with and without DM2, and to relate the lesions to cognitive performanceSecondary Objective(s): 1) To characterize cerebral microinfarcts at 7T and…
The purpose of this study is to gain insight into the effects of auditory pacing on the stability and flexibility of hemiplegic gait coordination. It will be examined how auditory pacing can be best administered to improve the quality of hemiplegic…
To compare the (cost-)effectiveness of early surgical hematoma evacuation versus a conservative treatment in elderly patients with a traumatic ASDH.
The primary objective is to evaluate longitudinal developmental changes in brain structure in patients aged 6-18 years with SCD. The secondary objective is to analyze the longitudinal relations between biomarkers, demographic characteristics, brain…
Objective: 1. To determine whether vascular reactivity is lowered in memory clinic patients with mixed and pure AD pathology. 2. To define whether vascular reactivity upon visual activation is associated with CAA or with other small vessel disease (…
Primary objective: describe the longitudinal changes of Aβ38, Aβ40, Aβ42, and Aβ43 concentrations in CSF of patients with CAA, AD, and healthy control cases and estimate the differences in change between those groups.1. Explorative study to…
To investigate longitudinal changes in VR in patients with subjective cognitive impairment (SCI), mild cognitive impairment (MCI) and AD dementia compared with controls. To investigate whether VR predicts progression of disease severity (cognitive…
Objective and Research QuestionsTo identify predictors of brain outcomes in HHT patients, we propose to leverage our multicenter network of HHT Centers to characterize comprehensive brain outcomes.Study Aims:Aim 1: We hypothesize that the presence…
Primary aim: Examine whether and to what extent fatigue and quality of life of patients with SAH improve after participating in RE-SAB.Secundary aims: (1) Examine whether and to what extent physical activity level, physical fitness, coping style,…