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Joint distraction as a treatment for end stage knee osteoarthritis: a comparison with presently applied surgical alternatives.

1. Is KJD clinically non-inferior to current surgical techniques (HTO and TKP)?2. Is KJD superior to HTO in actual structural repair of cartilage?3. Is KJD cost-effective in the long-term compared to HTO and TKP?

Difference in Patient Reported Outcomes at 1 year after 6 or 8 weeks of carpometacarpal joint distraction: a Randomized Controlled Non-Inferiority Trial.

Primary Hypothesis: - There is a difference in PROMIS Physical Function Upper Extremity Short Form (PROMIS PF UE SF) score between group A (6 weeks distraction) and group B (8 weeks distraction) at 1 year after first carpometacarpal joint…

Osteochondral lesions under 15mm2 of the Talus; is iliac crest Bone marrow Aspirate Concentrate the Key to success?

The main objective of the present study is to compare the clinical outcome of bone marrow stimulation alone versus bone marrow stimulation and bone marrow aspirate concentrate (BMAC) for small symptomatic osteochondral defects of the talus.

Determining the causative agent and optimal duration of antibiotic therapy in persons with diabetes and foot osteomyelitis: BonE BiOPsy (BeBoP) trial

Primary Objective: To prospectively compare outcomes of subjects with diabetic foot osteomyelitis treated with antibiotics targeted at culture results from bone biopsy (intervention group) versus therapy targeted at ulcer bed biopsy culture results…

Effectiveness of pain neuroscience education on pain after total knee arthroplasty: a randomised controlled trial

The main objective is to compare the effectiveness of two sessions PNE versus care as usual on pain levels 3 months after surgery in patients undergoing TKA. Secondary objective(s) is to explore the effectiveness of two sessions PNE in comparison to…